vasopressin and thyroid drugs Flashcards
what does ADH do
increase water retention
how does ADH function
- V2 receptor binds to GCPR
- PKA mediated phosphorylation of aquaporin
- retention of water channels in plasma membrane
second action of ADH
smooth muscle contriction via V1 receptors
location of smooth muscle contraction via ADH
- coronary vessels
2. greater GI motility
2 potential clinical uses of ADH
- local hemostatic during surgery
2. emerg. treatment of pulseless ventricular tachycardia
2 vasopressin drugs
- desmopressin - V2 receptor agonsist - longer acting
2. arginine vasopressin - V1 receptor agonist - shorter acting
side effects of vasopressin drugs
V1 - vascular and GI effects
V2 - water intoxications
2 potential antagonists
- SAMSCA - V2
2. Vaprisol - V1/V2
2 different thyroid drugs and their replacement
- levothyroxin (synthroid) - T4
2. liothyronone - T3
what is drug of choice and why
levothyroxin because body can convert as needed
average levothyroxine dose
125ug
2 special populations for thyroid drugs
- elderly -start small and move up
2. pregnancy - 1.5 x normal dose to make sure fetus is getting it
2 potential problems with the drugs
- toxicity
2. hyperthyroidism
problems with different brands
not all brands have bioequivalence
treatment of hyperthyroidism
thionamides (propylthiourracil and methimazole)
