Back and limb dev Flashcards
tissue sources for intervertebral discs
paraaxial mesoderm
direction of dev of vert.
cranio>caudal
Tissue dev from the side of somites (3)
- dorsolateral - dermomyotome - dermis
- dorsal and ventral - myotome - striated muscle
- ventromedial - sclerotome -
tissue dev from side of myotome
- dorsal - back muscle
2. ventral - rest of body muscle
3 sclerotome directions and their devs.
- ventomedial - vert. bodies and disc
- dorsomedial - neural acrches and meninges
- ventrolateral - transverse process and ribs
Disc are segmental or intersegmental
segmental
vert. are segmental or intersegmental
inter
defects of sclerotome dev (3)
- hemivert. - lacking somite dev on one side
- fusions
- spina bifida - vert arch not formed
types of neural tube spina bifida (2)
- myloschisis - open spinal cord
3. mylomeninggocele - produces sac out skin
types of vert spina bifida (3)
- occulta - small gap
- meningocele
- meningomyelocele
2 areas of interaction for limb dev
lateral mesoderm and wolfian plate
expression of what leads to limb bud dev
FGF-10
where does and apical ectodermal ridge (AER) form ?
where dorsal and ventral ectoderm meet
3 types of org. involved in limb dev. and area and their signal modelcules
- proximodistal - AER - FGF
- craniocaudal - ZPA - SHH
- dorsoventral - ectoderm - Wnt-7
Features of proximodistal org.
cells leaving later become more distal
