Gastric CA Flashcards
1
Q
main type of gastric CA
A
adenocarcinoma
- but also lymphoma, carcinoid
2
Q
2 main types
A
- intestinal types
2. diffuse type
3
Q
epi
A
2nd leading cause of CA death worldwide
- men>women’
- regional variation
4
Q
main intestinal type risk factor
A
h. pylori - via chronic inflammation
5
Q
other intestinal risk factors
A
- diet (salt, nitrites)
- obese
- smoking
- prior surg
6
Q
risk for diffuse type
A
- younger
- hereditary in some
- mutation in e-cadherin
7
Q
2 classification systems
A
lauern (diffuse vs. intestinal)
WHO - not used
8
Q
what is seen in intestinal type
A
central ulcer in folds
9
Q
what is seen in diffuse type
A
signet rings
- mucin vacuoles
10
Q
what does grading tell us
A
how fast - degree of differentiation
11
Q
what is grading scheme
A
G1-G4 - with 4 being least diff.
- diffuse type is automatically G3
12
Q
what is stage based on (3)
A
TNM
13
Q
what are 3 margins
A
- proximal margin - eso
- distal - duodenum
- omental (radial) margin
14
Q
3 additional parameters
A
- lymphatic invasion (small vessel)
- venous
- perineural
15
Q
clinical features
A
if early - asymtomatic
- weight loss
- Fe def.
- obtruction
