Geri pharma Flashcards
1
Q
def. adverse drug event
A
an injury resulting from admin of a drug
2
Q
3 pharma factors influenced by ageing
A
- pharmcokinteitc - how body handles drugs
- pharmacodynamics - how drug affects body
- drug-drug interactions
3
Q
4 parts of pharmacokinetics
A
- absorbtion
- dist.
- meatbolism
- elim
4
Q
what influences a drug’s bioavailality
A
- drug liberation
- gastic motlity
- drug properties
- drug transporters
- drug metabolsim
5
Q
2 gastic issues with age
A
- higher gastic pH
2. less motility - slower to act
6
Q
how to change oral dosing with age
A
- no sig. need to change practices
7
Q
what are 3 effects of aging skine
A
- sun exposure
- less blood supply
- less water contenet
8
Q
3 ways vol. of dist changes with age and how it affects
A
- more fat
- longer half life of lipoohillic drugs - benzos - less water
- larger conc. of lipo phillic drugs - digoxins - less protein binding cap
9
Q
2 phases of metabolism and how they change with age
A
- CYPs
- decreases by 30%
- CYPs
- conjugation
- no chnage
overall need to give a lower loading dose
10
Q
2 general ways drugs are removed
A
- passive - renal
2. active - drug transporters
11
Q
how does renal function change
A
- less nephrons
- less blood flow
- less GFR
- need to be cautious about renal drugs
12
Q
3 renal drugs to be extra careful with
A
- lithium
- digoxin
- sulfonourea
13
Q
ADME summary
A
A - less acid in stomach
D - langer half life and altered C
M - less liver metabolism
E - less kidney function
14
Q
2 main dynamic changes with age
A
- drug-drug interaction
2. increased sens. to cog effects
15
Q
3 more sens to and 2 less sens. to
A
more - sedatives - opiods - antichol less - BB - A stims
