Dementia Flashcards
def. dementia
symptom on neuro degenetative disease
biggest risk for dementia
age
what are 6 neuro conditions associated with dementia
- alz - most common
- lewy-body
- parkinson
- fronto-temporal
- progressive supranuclear palsy
- corticobasal syndrome
def. alzheimers
cog. deficits are evident on Hx and exam in one of 2 following cats:
1. amnetic presnetation
- most common
- impairment of learning and recall
2. non-amnestic
- language
- visual
- executive
what is between normal and alz
mild cog. impariment
what is lewy body
- diffuse atrophy dementia plus 2 of - fluctuation - visual halluc - parkinsonism
what is parkinson dementia
tremor/rigidity + dementia
what is vascular dementia
tend to have vascular risk factors dementia + probable VaD - clear temporal relationship possible VaD - unclear temporal relationship
what is fronto-temporal degen
family of syndromes
what is behvioural variant FTD
change in personality Possible (3/6) - disinhibition - apathy - loss of emotional reactivity - perseverative, sterotyped behavior - hyperorality, eating changes - executive issues
what is primary progressive aphasia
clincal syndromes that involve language impairments selectively, or early on
what is semantic variant PPA
hemisphere affected determines issues
Left
- loss of meaning for words, objects, emotions
Right
- behavioral and social conduct
- loss of person based semantic knowledge
- loss of empathy and ability to recognize emotions
what is non-fluent variant PPA
- disorder of expressive language and speech production
- behavior/insight preserved early on
what is extending term FTLD
some shit I don;t get
what test can aid in diagnosis of alz
CSF: A-beta, Tau
def. of mild cog. impariment (4)
- concern regarding change in cognition
- impairment in one or more cog domains
- preservation of independence in functional abil
- not demented
***Top ten on DDx for alter cog. behaovior
Alz Vasc Drugs Ethanol Medical/metabolic Eendocrine, ears, eyes, env Neurologic Tumor, toxin, traums Infection, idiopathi, inflammation Amnesia, autoimmune
2 basic premise to Tx
- interfere with formation of toxic substances
2. remove substances
5 meds for alz
- Ach-esterase inhibs
- NMDA-r antagonists
- SSRIs
- atypical antipsych
- other
Tx for frontotemporal
- none avaialbel
- antideps and anti-psych
- possible TAU in future
3 meds for parkinsons
- DOPA
- Ach-esterase inhibs
- anti-dep
Tx for vascular dem
control vascular risk factors
- BP, sugar, lipids
- exercise
what is important about first Sx
- clue to anatomy and neurophys
- ## diagnosis required for prognosis
5 common first Sx in AD
- missing appointments
- losing keys
- repeating stories
- repetitive Qs
- lost
6 1st Sx in frontotemporal dem
executive function
- disinhibition
- pers. change
- lack of concern for others
- apathy
- overeating
- lack or planning/organization
first Sx with lewy body
- movement
- hallucinations
- REM motor behavior
