Drug targets Flashcards
1
Q
what are pharmacokinetics
A
what the body does to the drug
2
Q
what are 4 aspects of pharmacokinetics
A
Absorption, Distribution, Metabolism, Excretion
3
Q
what are pharmacodynamics
A
what the drug does to the body - drug action
4
Q
4 aspects that keep a drug in plasma
A
- large
- charged
- bind to plasma proteins
- transported by passive diff
5
Q
2 aspects of drugs that get into extracellular compartments
A
- small
2. polar
6
Q
type of drugs that get into cells
A
hydrophobic
7
Q
how do most drugs work
A
bind to cell surface receptors
8
Q
5 protein drug targets
A
- ion channels
- membrane bound receptors
- enzymes
- intracellular receptors
- pumps and transporters
9
Q
3 non-protein drug targets
A
- lipids
- ions
- water
10
Q
rank bond strengths
A
van de waals<covalent
11
Q
3 features of covalent bonding drugs
A
- share e pair
- irreversible
- effects last long time after drug taken
12
Q
what is an agonist
A
- affinity for receptor that causes cell changes
2. intrinsic activity
13
Q
what is antagonist
A
- affinity for receptor but doesn’t make change
- no intrinistc effects
- make change by attenuating agonist effects
14
Q
4 major receptor families
A
- ligan gated ion channel- lets ions in
- GCPR - 2ndry messenger system
- enzyme linked
- intracellular receptor
15
Q
what is fastest mech
A
ion channels
