Liver, pancreas Flashcards
what is CT capsule of liver
glissons capsule
what is liver peritoneum state
mostly intraperitoneal, so has perit except for bare area
what is structure unit of liver
lobule
7 contents of liver lobule
- hepatocytes
- sinusoids
- kupffer cells
- central vein
- space of disse
- Ito cells
- bile canaliculi
what is in a portal triad (3-4)
- hep. arteriole
- hep. venuole
- bile duct
maybe a lymph vessel
where does blood drain into in lobule
central vein
where does canaliculi drain into
bile duct
what keeps bile within canaliculi
tight junctions
4 causes of jaundice
- excess bilirubin production (too many RBC breakdown)
- reduced uptake - can’t get into liver
- decreased conjugation
- reduced excretion - block
what is bilirubin
leftover from breakdown of RBCs
what is bilirubin conjugation
attachment of glucouronic acid to allow transfer out of liver and body
what separates liver cell from sinusoid
space of disse
what are kupffer cells
monocytes that have migrated and become stuck and now phagocytose garbbage
what are Ito cells and what do they do
fat storage cells that may be responsible for liver cirrosis
what is path of blood out of liver
sinusoids>central vein>hepatic vein>IVC
2 other ways to organize a liver
- portal lobule - centered on bile duct excretion patterns
2. liver acinus - based on blood flow
layer of ble duct wall from in to out
- mucosa
- muscularis
- adventitia/serosa
which is serose vs. adventia
serosa - covered by peritoneum (outside)
adventita - liver side
what divides lobules of pancreas
CT capsule that extend inward
basic structure of exocrine gland
clusters of spherical galndular cells (acini) empty into intercalcated duct
what do acinar cells secrete
digestive enzymes
what is added by duct cells
watery alkaline fluid
what stims acinar cells
CCK
what stims duct cells
secretin
what are 3 cells types of endocrine glands and what do they secrete
- a cells (25%) - glucagon
- B cells (60-70%) - insulin
- omega cells - somatostatin
how to differentiate islets of lang from autonomic ganglia
islets have small round cells, while autonomic ganglia are larger
