Sublethal cellular responses Flashcards

1
Q

what is homeostasis

A

steady state maintained in response to physiological demands

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2
Q

4 possible responses to stress

A
  1. adaptation (plasias)
  2. Other cell alterations
  3. cell injury
  4. cell death
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3
Q

3 purposes of adaptive cell repsonses

A
  1. withstand stress
  2. adapt to stress
  3. restore tissues to normal function
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4
Q

4 types of adaptations

A
  1. hyperplasia
  2. hypertrophy
  3. atrophy
  4. metaplasia
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5
Q

def. hyperplasia

A

increase in # of cells, resulting in increased mass of tissue or organ

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6
Q

2 features of hyperplasia

A
  1. occurs in cells capable of replication

2. reversible

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7
Q

mech. of hyperplasia

A

stim of cell cycle by growth factors, more mature cells

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8
Q

4 pathologic hyperplasia

A
  1. endometrial
  2. prostatic
  3. ductal of breast
  4. repsonse to viruses
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9
Q

2 phsyiological hyperplasia

A
  1. hormonal

2. compensatory

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10
Q

def. hypertrophy

A

increase in cell size leading to larger organ

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11
Q

3 feat. of hypertrophy

A
  1. oft. coexists with hyperplasia
  2. cell enlargement
  3. reversible
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12
Q

mech of hypertrophy

A

increased synthesis of structural proteins and cellular components

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13
Q

2 physiological hypertrophy

A
  1. excercise

2. hormonal

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14
Q

2 pathological hypertrophy

A
  1. cardiac muscle

2. bladder muscle

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15
Q

def. atrophy

A

decrease in size and/or number of cells

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16
Q

is atrophy reversible?

17
Q

2 normal atrophy

A
  1. embryo

2. reversal of hyper

18
Q

mech of atrophy

A

increased protein degradation and decreased synthesis

19
Q

5 examples of pathological atrophy

A
  1. decreased worload
  2. loss of innervation
  3. loss of blood supply
  4. lack of nutrition
  5. loss of hormones
20
Q

def. metaplasia

A

change of one MATURE cell type to another

21
Q

4 feat. of metaplasia

A
  1. epithelial or mesenchymal cells
  2. adaptive to changing env.
  3. response to chronic irritation
  4. prob. not reversible
22
Q

normal metaplasia

A

ONLY one - squamous metaplasia in cervix

23
Q

mech of metaplasia

A

reporogrammming of epithelial stem cells

24
Q

4 patho metaplasias

A
  1. squamous meta of bronchi
  2. columnar meta of esoph
  3. intestinal meta of stomach
  4. squamous meta of bladder
25
3 other cellular alterations
1. aging 2. accumulation of cell contents 3. dysplasia/neoplasia
26
2 types of cell accumulations
1. normal - water, lipids, protein | 2. abnormal -endogenous or exogenous
27
4 features of accumulation
1. transient or perm 2. harmless of toxic 3. cytoplasm or nucl. 4. produced by the cell or just stored there
28
4 types of patho cell contents
1. steatosis (fatty) liver 2. gauchers 3. alzheimers 4. parkinsons
29
what is normal protein folding
translation and folded with help of chaperones
30
3 options if protein not folded properly
1. repair 2. ubiquitin-proteasome degradation 3. cell damage and apop
31
what is amyloid
pathologic protein that is abnormall folded in B-pleated sheets - resitant to degradation
32
3 types of amyloid
AL - immunoglobin light chain AA - acute phase AB - alzheimers
33
what are prions
abnormally folded proteins that can cause other near proteins to fold - mad cow
34
def. neo and dysplasia
cellular alteration resulting in disordered or uncontrolled growth
35
def dysplasia
pre-malignant and MAY be reversible
36
def. neoplasia
refers to a tumor which has lost normal growth control and usually irreversible
37
mech in neoplasia
alterations in genes that control cell growth an survvial - esp in cells that proliferate
38
are dysplasic benign?
NOT neccesarily