Fat metabolism

Question 1

what is resp. quotient

Answer 1

CO2 produced/O2 consumed

Question 2

what is RQ for glucose

Answer 2

1 (6/6)

Question 3

what is RQ for fat

Answer 3

0.7

Question 4

3 main sources of ATP

Answer 4

1. fat – MAJOR
2. muscle glycogen
3. liver glycogen

Question 5

how is fat stored

Answer 5

as triglycerides

Question 6

what is a triglyceride

Answer 6

glycerol backbone with 3 fatty acid chains

Question 7

how does triglyceride breakdown work

Answer 7

1. perilipase A
2. 3 FA chains taken off and transported out on albumin
3. glycerol is left behind

Question 8

what happens to glycerol

Answer 8

to liver for glucogenisis

Question 9

what happens to FA chains

Answer 9

to liver and other muscle to be Acetyl CoA

Question 10

what is signal molecule for breakdown of fats

Answer 10

epinephrine

Question 11

how does epi work on fat cell

Answer 11

GCPR to increase cAMP and downstream signalling to perilipin

Question 12

why is caffeine helpful

Answer 12

inhibits PDE-5, which breaks down cAMP so we get more cAMP in fat cells and more breakdown

Question 13

what is FA activation and why is it important

Answer 13

changes from a polar molecule and stops it from getting stuck in the membrane

Question 14

what part of mito is difficult for crossing

Answer 14

inner membrane

Question 15

how does Acyl CoA get into mito

Answer 15

carnitine shuttle via translocase

Question 16

what is carnitine pathway

Answer 16

CAT 1 > tranlocase > CAT2

Question 17

how does FA inhibitions work

Answer 17

malonyl CoA inhibits CAT1 - can’t get it in

Question 18

how many rounds of oxidation does a 16C CoA go through

Answer 18

7

Question 19

what is final product of fatty acyl CoA

Answer 19

108 ATP

Question 20

what is hitting the wall

Answer 20

not enough glucose to allow FA to be converted

Question 21

why is glucose needed

Answer 21

need oxaloacetate for a more efficient krebs cycle