chronic inflammation Flashcards
3 requirements for resolution of acute inflammation
- short lived
- very limited damage
- capacity for cell regeneration
3 possible outcomes of acute inflammation
- resolution
- healing - fibrosis - scarring
- chronic inflammation
def. chronic inflammation
inflamm. of prolonged duration in which inflammation, tissue injury, and attempt to repair co-exist
2 things that chronic inflammation is trying to resolve
- continuous injury
2. dysregulated immune repsonse
3 cardinal features of chronic inflammation
- a component of non-neutrophilic inflammation (macro, lymphocytes, plasma cells)
- architectural destruction
- tissue fibrosis
what are macrophage stages
- marrow
- into blood -monocyte
- into tissue as macrophage or activated macrophage
what happens to macrophages in tissues
either goes to towards healing/repair pathway or proinflmmatory pathway
what happens with persistent injury
INF-Gamma causes granulomatous inflammation
def. granuloma
collection of activated macrophages surrounded by chornic inflammation
def. granulomatous inflammation
distinctive pattern of chronic inflammation resulting from an antigen that is difficult to eradicate
2 types of granuloma
- immune granuloma - poorly degradable antigen or paticle causes cell mediated inflammation
- foreign body - something too large to phag.
2 types of perisisent injurious stim.
- persistent infeciton - myobacteium - abundant INF-G
2. insoluble inert substance
3 types of immune related chronic inflammation
- autoimmune
- immune dysregulation
- hypersensitivity reactions
what is autoimmune reaction
persistent and eccessive stimulation due to self-antigen
what is immune dysregulation
(IBD) - unregulated response to microbes
