RBCs Flashcards
1
Q
foundation of Hb
A
heme+globin
2
Q
function of heme
A
carries O2 and CO2
3
Q
function of globin
A
structure and protection of heme
4
Q
different types of Hb and when
A
HbA - adult
HBF - fetal
HbE - embryo
5
Q
structure of HbA
A
- 4 subunits=4 O2
- a2B2
6
Q
2 states of Hb and affinity
A
relaxed - high O2 affinity, low CO2
tense - low O2 affinity, high Co2
7
Q
what changes affinity
A
15 degree rotations
8
Q
what does myoglobin supply
A
muscle
9
Q
diff between Mb and Hb
A
Mb is monomer - no cooperativity
10
Q
why do we need Mb
A
takes O2 from Hb at low sat points and brings to muscles
11
Q
what does acid do
A
- moves Hb affiinty curve to right
- Hb less affinity at low O2 sat. levels
12
Q
what shifts curve to R (3)
A
- acid
- diphosophglycerate
- high temp
13
Q
what shifts curve to L (4)
A
- high pH
- low temp
- high CO
- fetal Hb
14
Q
what is count of Hb
A
HgB - amount of protein in blood
15
Q
formula for hematocrit
A
Hgb x 3 - percent og blood that is RBC
