Parenchymal diseases Flashcards
1
Q
3 types of parenchmal diseases
A
- glomerular
- tubointerstitial
- vascular
2
Q
what is glomerular funciton
A
filtration (GFR)
barrier to cells and proteins
3
Q
clues to a renal level disease
A
- systemic features
- HT
- mild-mod ECF overload
- anemia/thrombopenia
4
Q
**2 clinical presentations of glomerular disease
A
- nephotic syndrome
2. nephritic
5
Q
4 features of nephrotic
A
HELP 1. Hypoalbumen 2. Edema 3. Lipidemia 4. Proteirnuria >3.5/day NON-proliferative - can ONLY be caused by glomerular disease
6
Q
4 features of nephritic disease
A
- HT
- hematuria
- proteinuria - small
- acute kidney injury
PROLIFERATIVE
7
Q
what is patho classification of glomerular disease
A
- non-prolif.
- glomerulonephroPATHY
- present with nephrotic syndrome - prolif
- glomerulonephITIS
- presents with nephritis syndrome
- RBC casts
- EMERGENCY
8
Q
4 causes of cell prolif.
A
- deposition of immune complexes
- post -infecious
- SLE
- Hep, HIV - AB depsition within glomerulus
- dysregulation of complement system
- idio
9
Q
what is work-up for prolif
A
- look for the things that could be causing
- biopsy
10
Q
3 different patho types of prolif
A
- mesangial cell
- endothelial
- epithelial
11
Q
main cause of mesangial cell
A
IgA neprhopathy
- HIV, cirrossis, celiac
12
Q
2 main causes of endo
A
- lupus
2. post-infectious glomerulonephritis
13
Q
2 potential outcome of lupis
A
- proliferative
- non-proliferative
- depends on where complexes get stuck
14
Q
patho feature of epithelial
A
cresenctric GNs
- most aggresive form of glomerular disease
15
Q
3 main patho sub-types of epithelial
A
- linear GBM staining - anti GMB disease
- coarse/granular staining
- SLE
- post-infesctious - little or no stain
- ANCA vasculitis
