Neonatal path. Flashcards

1
Q

def. birth

A

complete expulsion or removal of fetus that at any time did breath or show signs of life

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2
Q

def. premature

A
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3
Q

def. postmature

A

> 42 weeks GA

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4
Q

what is small and large for GA

A

90th

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5
Q

def. neonatal period

A

birth to one month

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6
Q

how does mortality compare to premature

A

inverse relationship - big jump between 24 and 23 weels

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7
Q

2 main causes of neonatal death

A
  1. premature

2. congential/chromo anomalies

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8
Q

5 parts of apgar

A
  1. heart rarte
  2. resp. effort
  3. muscle tone
  4. response to cath. in nostril
  5. color
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9
Q

how does apgar compare to mortality

A

high score = less death

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10
Q

3 fetal circ. bipass systems

A
  1. ductus venosus - liver
  2. foramen ovale - lungs
  3. ductus areteriosus - lungs
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11
Q

what happens to circ at birth

A
  1. pulm art. dilate and reduce pressure
  2. high LA pressure and low placental flow close foramen ovale
  3. duct arteriosus and venosus close
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12
Q

what happens to lung as age

A

get more alveoli - can survive at 36 weks

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13
Q

what happens to lungs at birth

A
  1. vag pressure squeezes fluids from lungs
  2. alveoli inflate with first few breaths
  3. alveoli don’t collapse b/c of surfactant
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14
Q

where does sufactant come from

A

type 2 pneumocytes

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15
Q

when do we have enough surfactant

A

35 wks

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16
Q

what is sufactant made of and what is important ratio

A

lecitin and shynogmyelin - need > 2:1 L:S

17
Q

3 general causes of failed adaptation

A
  1. immaute physiological systems
  2. congenital malformations
  3. supression of central controls and reflexes - no practice breathing
18
Q

2 causes of pulm. hypoplasia

A
  1. ogliohydramnos - too little fluid

2. fetal hydrops - too much fluid

19
Q

2 types of congenital heart malformations

A
  1. obstructions to circulation

2. persistence of fetal shunts

20
Q

def. congenital cardiomyopathy

A

thickening of LV so can’t contract and relax

21
Q

5 birth factors

A
  1. breech
  2. forceps/vacuum assisst
  3. large bb
  4. cephalopelvic
  5. prolonged labor
22
Q

3 traumas caused by birth

A
  1. head injuries
  2. fractures
  3. rupture/laceration of organs
23
Q

most common cause of neonate mortality

A

prematurity

24
Q

3 placental causes of prematurity

A
  1. premature rupture of placental membranes
  2. chorioamnionitis
  3. other - twins, placenta previa
25
Q

2 important complications of prematurity

A
  1. hyaline membrane disease

2. necrotizing enterocolitis

26
Q

def. hyaline membrane dissease

A

acute injury to alveoli and term. bronchioles with epithelial necrosis, exudation of fluid and formation of membranes in distal airspaces

27
Q

signs of HMD

A

tachypnea, hypoxia, increased work brething

- ground glass CXR

28
Q

how does HMD compare to age

A

inverse relat.

29
Q

main cause of HMD

A

lack of suractant

30
Q

2 main complications of treatment of HMD

A
  1. pulmonary barotrauma - high pressures used
    - reparative proliferation and metaplasia of stroma
  2. oxygen toxicity - bronchopulm. dysplasia
    - pulmonary fibrosis, arrest in dev. of acini, decrease cap. bed
31
Q

clinical def. of pulmonary dysplasia

A

persistence of Sx of resp, disease beyond the neonatal period

32
Q

HMD prophylaxis (3)

A
  1. delay birth
  2. give steroids
  3. exogenous surfactant
33
Q

what does HMD prog. depend on

A

GA and birth weight - better now with surfactant

34
Q

what is necrotizing enterocolitis (NEC)

A

acute iscemic necrosis of the intestines of a newborn

35
Q

3 poss. causes of NEC

A
  1. dev. after feeding starts
  2. assoc. with poor perf. of intestines
  3. assoc. with bact. invasion through damaged mucosa
36
Q

NEC path.

A
  1. necrosis begins at bowel mucosa and progresses full thickness
  2. mucosa blees
  3. bubbles of gas form in bowel wall
  4. necrosis leads to bowel perf.
37
Q

NEC treatment and prog.

A
  • early treat with ABs and bowel rest (TPN)

- 40% require resection