Thyrotoxicosis Flashcards
1
Q
Sx of thrytoxicosis
A
hyper, but tired
- lose weight
- agitatetd, insomnia
- sweating and heat intolerance
- diarrhea
- muscle weakness
2
Q
tests for hyper
A
- TSH, T3-4
- serum K - eating disorders
- ECG
- B-HcG
- CBC - underlying disease?
3
Q
what will be seen in hyper
A
low TSH and high T3-4
4
Q
2 things when find hyper
A
- B-blocker
2. urgent referral to endo
5
Q
Sx on exam for hypoer
A
- silky warm sweaty skin
- tremor, hyperrelfexic
- thyroid large and non-tender, no nodules
- proptosis in graves
- ## arryhtmias
6
Q
DDx for hyper (6)
A
- graves
- toxic multinoduclar goiter
- subacute thyroiditis
- ingested iodine
- exogneous thyroid
- other rare
7
Q
3 ways TSH-r may be stimulated
A
- TSH autoimmune antibodies - graves
- beta-HCG related TSH-r activation
- activatine TSH-r genes
8
Q
what is seen on histo of graves thyroid
A
no colloid
9
Q
what is multinodular goiter and follicular nodular disease
A
- impaired synthesis of thyroid hormone
- usually euthyroid
- hyperplastic vs. neoplastic
- mech is activation of cAMP pathway in thyroid
10
Q
what is mech of subacute thyroididits
A
destruction of colloid containing follicle - releases t34
- may be inflam or mechanical
11
Q
what is mech of increaed iodine load
A
intake leads to increased uptake and production of hormones
12
Q
how to diagnose the type of hyper thyroid
A
radioactive iodine uptake
13
Q
common and high RAI types (3)
A
- graves
- MNG
- toxic adenoma
14
Q
common and low RAI (2)
A
- subacute thyroiditis
2. exogenous
15
Q
uncommon and high RAI types (2)
A
- TSHoma
2. b-HCG stimulated
