Pharmacology of gonadotrophic hormones Flashcards
1
Q
primary aim of birth BCPs
A
prevent ovulation
2
Q
2 hormones in most BCPs and what they do
A
- est - sensitizes hypo and pit to progesterone
- progenstin - feedback inhib of FSH and LH prevents LH surge for ovulation, also oppses proliferative effects of E on uterus to prevent cancer, thickens cervical mucus
3
Q
main form of E in BCP
A
ethinyl estradiol
4
Q
main form of progestin
A
nor-testosterone derivatives
5
Q
what is BCP fixed daily dose?
A
21 days on with 7 days off - period 3 days after being off
6
Q
what are 2 phasic formulations
A
- synphasic
2. triphasic - bounce up in three stages
7
Q
what are 2 BCPs with shortened hormone free intervals
A
seasonale and seasonique - 84 days and then period
8
Q
side effect of shortened periods
A
breakthrough bleeding
9
Q
7 benefits of BCPs
A
- effective
- less menstruation
- less iron anemia
- less benign breast disease
- less ovarian cancer
- less endometrial cancer
- less osteoporosis/colon cancer??
10
Q
5 risks of BCP
A
- thromboembolitic
- nausea, edema, headache
- potential for diabetes - glucose tolerance
- hypertension
- liver disease
11
Q
what are 2 major risks for BCP
A
- age over 35
2. smoking
12
Q
what is better for women over 35
A
alesse - lower estrogen
13
Q
absolute contraindications for BCP (7)
A
- thromboembolic disease
- cerebrovascular disease
- impoared liver
- Est dependent carcinoma
- uterine bleeding
- pregancy
- migraine
14
Q
relative contraindications for BCP (3)
A
- hypertension
- elective surgery
- gestational diabetes
15
Q
3 drugs that decrease efficacy of BCPs
A
- anticonvulsants
- antibiotics
- sedatives
