CSF and BBB Flashcards
what is Fx of CSF
bouyancy to prevent BV and N compression and prevent bouncing around
what is CSF derived from and how often
from blood and cleared 3x per day
what is lining of ventricles and central canal
ependyma
what are 2 components of BBB
- blood ISF barrier
2. blood CSF barrier
what creates BBB-ISF barrier
tight jcts between endothelial cells of the capillaries mean all must pass through endothelial cells
what can pass though an endothelial cell
water, gas, lipid solubles, small molecules
what forms the blood CSF barrier
choroid plexus
what does choroid plexus do
secretes CSF into vent. space
what is CP located
in lat, 3 and 4 ventricles
what is a choroid plexus made up of
blood vessel with choroid ependymal cells overlaying it
what is BBB in CSF
fenestrated caps., but ependyma have tight jcts that stop junk from going through
what are 3 openings for CSF in 4th vent
- median apeture
2. 2 lateral apetures
where are 2 places CSF taken back up
- via arachnoid granulations
2. sheaths of cranial and spinal nerves into lymph system - especially into olfactory tract for mucosa
what are 2 types of hydrocephalus
- obstructive -blockage
2. communicating - not reabsorbing
what are features of 2 types
- obstructive - location indicated by where the vent. is enlarged
- comm. - all vents enlarged
