Tumor-host interactions Flashcards
how does host recognize tumor
tumor antigens
3 types of tumor antigens
- products of mutated genes
- overexpresses or aberenttly expressed genes
- tumor antigens produced by oncogenic viruses
what are products of mutated genes
mutations in proto-oncogenes and tumor supressor genes
2 types of over/aberantly expresses proteins
- if express one that was normally only minimally expressed will set off signals
- proteins that were normally hidden (testes)
what kills prododucts of oncogenic viruses
CD8 cells recognize and kill
2 types of cell mediated immunity against tumor
- CD8
- NK cells - don’t need prior sensitization
- kill cells without MHC
do macrophages kill
yes, in concert with T and NK cels
what do antibodies do
not much help
- monoclonal ABs being developed against specific receptors
6 ways that tumors escape detection
- selection of antigen negative cells
- loss or reduced expression of MHC -may activate NK cells
- lack of co-stim
- immunosupression (TGF-B production)
- antigen masking
- apoptosis of cytotoxic T-cells (fas-fasl) binding
5 effects of tumor on host
- physical/load effects
- functionality of tumors
- paraneoplastic sndrome
- cachexia
- immunosupression
what types of tumors cause phsycial/load effects
both benign and malignant
what is load effects
- obstruction or impingment
- impaired organ function
- pain
- CNS dysfunction
what is effect of functionality of tumors
tumors arising from cells with secretory functions
type of tumor to create more functionality
benign more common
def. paraneoplastic syndrome
symptom complex that cannot be explained by local or metastatic spread of tumor
- from hormones not normally produced there
