Intro pharmacology and pharmacokinetics Flashcards

1
Q

def. of therapeutics

A

treatment of diseases

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2
Q

top 5 reasons for PT visits

A
  1. HT
  2. Diabetes
  3. Check-up
  4. Depression
  5. Anxiety
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3
Q

% of visits getting drugs

A

59%

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4
Q

5 main classes of drugs

A
  1. natural preparations
  2. pure compunds - morphine
  3. semi-synthetics - heroin
  4. purely synthetic - most modern drugs
  5. biological products - many cancer drugs
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5
Q

what is chemical name

A

describes the chemical structure

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6
Q

what is drug company code

A

used by pharma in early dev.

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7
Q

what is generic name

A

officially approved name - ibuprofen

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8
Q

what is proprietory name

A

brand name - advil

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9
Q

what is street name

A

used on the street - exctacy

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10
Q

2 key areas of pharmacology and define

A
  1. phramacokinetic - what body does to drug

2. pharmacodynamics - what drug does to body

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11
Q

2 main steps in figuring out drugs

A
  1. what is drug taget and agent

2. how do we get the drug there

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12
Q

factors to take into account about drug

A
  1. efficacy
  2. safety
  3. route of admin
  4. route of elim
  5. cost
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13
Q

factors to take into account with person

A
  1. demographics
  2. medical conditions
  3. personal factors
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14
Q

Path of drugs in body

A
ADME
Absorbed
Distributed (redistributed)
Metabolized
Excreted
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15
Q

2 main types of drug admin

A
  1. enteral - in the gut

2. parenteral - beside the gut (skin, blood)

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16
Q

diff between topical and transdermal

A

topical - one spot only

transdermal - through the skin to system

17
Q

where are most orally drugs absorbed

A

small intestine

18
Q

what is first pass effect

A

biotransformation of drug (active or inactive ) before it reaches the site of action

19
Q

main place of transformaiton

A

liver

20
Q

what does first pass effect affect

A

bioavailability

21
Q

what is bioavailability

A

% of drug that reaches the site of action unchanged - comparison of route to IV route

22
Q

what is calculation for bioavailability

A

AUCextravascular/AUCintravenous

23
Q

what is bioequivalence

A

basically that a new drug is used in the same way as the one it is trying to replace

24
Q

what is therapeutic equivalence

A

comparable clinical effectiveness between drug products

25
Q

what is a prodrug

A

drug itself is active, but body transforms to active form