Extra for exam

Question 1

Site of embryo hematopoeisis

Answer 1

yolk sac

Question 2

site of fetal hematopoeisis

Answer 2

aorto-gonad-mesonephros > to liver

Question 3

site of adult hematopoieis

Answer 3

marrow in and some move to thymus

Question 4

2 location of HSCs

Answer 4

resting - surface of bone - endosteal niche

active - endothelium - vascular niche

Question 5

what mobilizes HSCs

Answer 5

G-CSF

Question 6

signalling pathways started by Epo and Tpo

Answer 6

JAK

Question 7

where is tpo released from?

Answer 7

bone marrow

Question 8

what happens in mutations of JAK

Answer 8

increased RBC or platelet diff. w/out EPO or TPO

Question 9

WBC equivalent of Epo or Tpo

Answer 9

G-CSF

Question 10

which Hb state has higher O2 affiinity

Answer 10

relaxed state

Question 11

2 types of dyshemoglobinemias

Answer 11

1. methemoglobin - Fe3+

2. carboxyhemoglobin - bound to CO

Question 12

attractor for bone marrow cells

Answer 12

SDF-1

Question 13

factors that are Ca dependant and bind to PS on surface

Answer 13

prothrombin and X, 9

Question 14

2 proteins that act as inhibitors of thrombin generation

Answer 14

A and C

Question 15

what is philadelphia chromosome

Answer 15

9:22 tranlocation

Question 16

Causes of macrocytosis

Answer 16

F - folate
A - alcohol/drugs
T - Thyroid
R - retics.
B - B12
C - cirhosis