The action potential Flashcards

1
Q

what are muscle spindles

A

stretch receptors of skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what happens when stretch the mechanoreceptors

A

opening of Na channels causing receptor potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what type of potential are receptor potentials

A

graded - good for strength coding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what happens to receptor potentials over space

A

decremental - decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does action potential begin

A

spike initiation zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how is info coded in action potential

A

frequency and pattern of AP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

5 phases of an AP

A
  1. resting
  2. rising
  3. overshoot
  4. falling (repolarizing)
  5. hyperpolarization
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is AP threshold

A

minimum voltage that must be reached to initiate - 55mV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what happens with more depolarization

A

more frequent AP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what limits AP frequency

A

refractory period (absolute or relative)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what opens with AP

A

Na and K channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

which channel opens faster

A

Na, and K sustains over depolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are 3 states of Na channel

A
  1. resting
  2. activated
  3. inactivated
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what reverses inactivation of Na channel

A

regaining -70

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what happens during threshold phase

A

inward Na> outward L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what happens during rising phase

A

rapid opening of Na channels

17
Q

what happen in overshoot

A

Na inactivation and delayed opening of VG K channels

18
Q

what happens in falling phase

A

Na inactivation and K

19
Q

what happens in hyperpolarization

A

residuale VG K and IL

20
Q

what happens in absolute refractory period

A

Na channel inactivation prevents AP generation

21
Q

what is direction of Na channel propagation of channel

A

orthodromic

22
Q

what determines speed of conduction

A

length of membrane

23
Q

what happens with larger diameter axon

A

less axial resisitance- faster conduction

24
Q

what forms myelin in PNS and CNS

A

PNS - schwann cells

CNS - oligodendricites

25
Q

what are interuptions in myelin

A

nodes of ranvier

26
Q

what is conduction that jumps along nodes

A

saltatoy conduction

27
Q

what are diseases that demylenate PNS and CNS

A

PNS - guillain-barre

CNS- MS

28
Q

how does local anasthetic work

A

blocks Na channels of pain fibers so can’t give signal