Herpesviridae Flashcards

1
Q

what is Herpes structure

A

double stranded DNA with an envelope

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2
Q

where does replication occur

A

in nucleus of infected cells

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3
Q

how many herpes visuses

A

8 - all species specific

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4
Q

where does HSV 1, 2 and VZV stay latent

A

sensory and cranial nerve ganglia

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5
Q

where does CMV, and HHV 6 stay latent

A

monocytes, macrophages, CD34 cells

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6
Q

where does HHV- 7 stay latent

A

CD4

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7
Q

where does EBV stay latent

A

memory B cells

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8
Q

where does HHV8 stay latent

A

B cells

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9
Q

what is only HV that can be tranmitted by aerosol

A

VZV

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10
Q

2 HV that can be transmitted by blood

A

CMV and HHV 8

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11
Q

how does HV transmit

A
  • not long lived outside

- may be transmitted during symtomatic or asymptomatic stages

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12
Q

what does transmission from primary infection cause in new person

A

primary infeciton

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13
Q

what does transmission from reactivation cause in new person

A

primary infectiokn

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14
Q

what percent of people with HSV2 are symptomatic

A

10-15%

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15
Q

where is most HSV1 and 2

A

1 - mouth

2 - genitals

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16
Q

what are other locations of HSV 1

A

cornea, hands, brain (baby)

17
Q

length of promary infection in HSV

A

1 - 10-14 days

2 weeks

18
Q

what is recurrence rate for HSV

A
    • 20-40%

2. - 60-90%

19
Q

what does HSV serology tell you

A
  • no reliable IgM test

that at some point you had it

20
Q

2 treatments of HSV

A
  1. support

2. antivirals can reduce duration, but must be taken within 72 hours

21
Q

what make VZV so contagious

A

infectious for 2 days before crusting

ariborne

22
Q

lifetime risk of reactivation of VZV

23
Q

3 syndromes caused by VZV

A
  1. chickenpox
  2. zoster (shingles) - scarring, post-herpetic neuralgia
  3. congenital - if mom had it in first20 weeks
24
Q

what are 2 most common dermatomal zoster places

A

chest and face

25
4 ways to diagnose VZV
1. clinical 2. serology for IgG and IgM (Acute) 3. direct detection - immunoflourecnces 4. isolation - vesicular fluid
26
treatment of VZV
acyclovir if severe
27
2 ways to prevent VZV
1. VZIg if in 72 hours | 2. vaccines for VZ and shingles
28
what is varicella vaccine
live attenuated vaccine - 95% AB response
29
what is zoster vaccine
live attenuated virsu - 50% effective
30
what is HHV 6
common and causes roseola infatum - not serious
31
what is EBV
most infection asymtomoatic - spread by sailva - fever, mal;aise , lymphadeopathy - associated with burkets lymphoma and pharyngeal carcimona
32
what is EBV diagnosis
1. no culture 2. PCR can monitor, but not diagnose 3. monospot (heterophile AB) is gold stnadard
33
what is CMV
acute is ustually asymptomotic - may be mono-like - severs seen in AIDS, transplants, neonates
34
what happens in congential CMV
- Sx in 25% - cytomegalic inclusion disease - jaundice, hepatosplenomegaly, petechial rash, microcephaly
35
what happens in HHV-8
healthy - febrile exanthem | immunocompromise- kaposi sarcoma, castlemans disease