Herpesviridae

Question 1

what is Herpes structure

Answer 1

double stranded DNA with an envelope

Question 2

where does replication occur

Answer 2

in nucleus of infected cells

Question 3

how many herpes visuses

Answer 3

8 - all species specific

Question 4

where does HSV 1, 2 and VZV stay latent

Answer 4

sensory and cranial nerve ganglia

Question 5

where does CMV, and HHV 6 stay latent

Answer 5

monocytes, macrophages, CD34 cells

Question 6

where does HHV- 7 stay latent

Answer 6

CD4

Question 7

where does EBV stay latent

Answer 7

memory B cells

Question 8

where does HHV8 stay latent

Answer 8

B cells

Question 9

what is only HV that can be tranmitted by aerosol

Answer 9

VZV

Question 10

2 HV that can be transmitted by blood

Answer 10

CMV and HHV 8

Question 11

how does HV transmit

Answer 11

• not long lived outside

- may be transmitted during symtomatic or asymptomatic stages

Question 12

what does transmission from primary infection cause in new person

Answer 12

primary infeciton

Question 13

what does transmission from reactivation cause in new person

Answer 13

primary infectiokn

Question 14

what percent of people with HSV2 are symptomatic

Answer 14

10-15%

Question 15

where is most HSV1 and 2

Answer 15

1 - mouth

2 - genitals

Question 16

what are other locations of HSV 1

Answer 16

cornea, hands, brain (baby)

Question 17

length of promary infection in HSV

Answer 17

1 - 10-14 days

2 weeks

Question 18

what is recurrence rate for HSV

Answer 18

1. • 20-40%

2. - 60-90%

Question 19

what does HSV serology tell you

Answer 19

• no reliable IgM test

that at some point you had it

Question 20

2 treatments of HSV

Answer 20

1. support

2. antivirals can reduce duration, but must be taken within 72 hours

Question 21

what make VZV so contagious

Answer 21

infectious for 2 days before crusting

ariborne

Question 22

lifetime risk of reactivation of VZV

Answer 22

30%

Question 23

3 syndromes caused by VZV

Answer 23

1. chickenpox
2. zoster (shingles) - scarring, post-herpetic neuralgia
3. congenital - if mom had it in first20 weeks

Question 24

what are 2 most common dermatomal zoster places

Answer 24

chest and face

Question 25

4 ways to diagnose VZV

Answer 25

1. clinical
2. serology for IgG and IgM (Acute)
3. direct detection - immunoflourecnces
4. isolation - vesicular fluid

Question 26

treatment of VZV

Answer 26

acyclovir if severe

Question 27

2 ways to prevent VZV

Answer 27

1. VZIg if in 72 hours

2. vaccines for VZ and shingles

Question 28

what is varicella vaccine

Answer 28

live attenuated vaccine - 95% AB response

Question 29

what is zoster vaccine

Answer 29

live attenuated virsu - 50% effective

Question 30

what is HHV 6

Answer 30

common and causes roseola infatum - not serious

Question 31

what is EBV

Answer 31

most infection asymtomoatic

• spread by sailva
• fever, mal;aise , lymphadeopathy
• associated with burkets lymphoma and pharyngeal carcimona

Question 32

what is EBV diagnosis

Answer 32

1. no culture
2. PCR can monitor, but not diagnose
3. monospot (heterophile AB) is gold stnadard

Question 33

what is CMV

Answer 33

acute is ustually asymptomotic

• may be mono-like
• severs seen in AIDS, transplants, neonates

Question 34

what happens in congential CMV

Answer 34

• Sx in 25%
• cytomegalic inclusion disease
• jaundice, hepatosplenomegaly, petechial rash, microcephaly

Question 35

what happens in HHV-8

Answer 35

healthy - febrile exanthem

immunocompromise- kaposi sarcoma, castlemans disease