Neuroplasticity Flashcards
what is neuroplasticity
ability of nervous system to reorganize/rewire its structure and function in response to internal and external stim
what is cellular mech of neuroplasticity
long-term potentiation - neurons that fire together wire together
what are 2 types of glutamate receptors and what do they do
- AMPA - glut binding allows Na in for depol.
2. NMDA - glut binding + depol. from AMPA allows Ca to come in
3 ways that LTP increase efficiency at synapse
- phosphorylation of AMPA receptors - open longer
- creation of new AMPA receptors - more receptors
- sprouting of new dendrites - more connectiosn
what is long term depression
opposite effect of LTP
what happens if only use digits 2 and 3
get more representation
what happens if cut off digit 3
digit 2 and 4 get more representation
what is learned non-use phenomenon
after not using a limb, it’s representation atrophies
solutions to non-use
constrain the other limb and give intensive therapy
what are 2 good signs in brain activity after a stroke
- more activity in damaged area
2. less activity in good area
what is drug reward pathway
drug>stim VTA>DOPA to NAc>get more drug
what happens in PFC in normals
normally will inhib. NAc so get less drug seeking behaviour
what happens in addicts
reward pathway takes over
2 types of TMS
single or repetititve
2 types of rTMS
- high freq - neuronal activation
2. low freq - neruonal supression
