Adverse drug reactions Flashcards
what is adverse drug event
something bad happens while taking the drug
what is adverse drug reaction
something bad happens due to the drug
what are type A reactions
dose related - too much of the normal reaction of the drug
what is type B reactions
- bizarre and idiosyncratyic
- not dose related- specific to the person
what is potential reaction to carmbemazepine
stevens johnson syndrome for people with specific HLA-B15:20
what are 3 issues for risk management in drugs
- plan before treatment
- care during treatment
- what to do in adverse event
4 things to be done before treatment
- informed consent
- determine toxicity risk
- baseline assessment
- communicate risk to PT
what is SAFER MD informed consent
Side effects Alternative treatments Forfeit of treatment Expected benefit Regimen for dosing Monitoring Duration of therapy
3 areas of primary prevention focus
- high risk drug
- high risk patient
- high risk situation
what are high risk drugs
interactions 4 As Antibiotics Anti-inflammatories Anti-convulsants Anti- coagulants
what makes PT high risk
contraindications
Age
health
genetics
what is a contraindication
DO NOT USE
what is warning
think and proceed before use
3 things to do during therapy
- recognize adverse event
- consider drug etiology
- determine association