brain tumors Flashcards
7 main questions to ask self about brain tumors
- in CNS: intracranial or extra cranial?
- if intracranial: intra or extra axial
- if intraxial: infra or supra tentorial
- if spinal: eaxta or intra canallicular?
- if intracanallicular: extra or intra dural
- if intradural: extramedullary or intrameddulary
7 primary tumor or mets?
4 DDx for CNS mass lesions in adults
- tumor
- vascular
- infectious
- inflammatory
5 post. fossa tumors in kids
- pilocytic astrocytoma
- ependyoma
- medualloblastoma
- choroid plexus papilloma
- choroid plexus carcinoma
what is pilocytic astrocytoma
- most common in children
- hydroceph or cellebellar dysfunction
- WHO gr1
what is imaging, path, goal of therapy, outcomes of pilocytic astrocytoma
imaging: cyctic lesion w mural node - may have strong contrast enhancement
path: biphasic appearance with comact fascicles
goals: surgery
outcome: 90% cure
**1 where are pediatric tumors
post. fossa
**2 signs of post. fossa tumors
cerebellar or hydroceph
**3 what are WHO gr1 tumors
non-infiltrative and curable
what are oligodendroglioma
- commonly present with seizure
- arise within cotex
- WHO gr.2
what is imaging, path, goal of therapy, outcomes of oligodendroglioma
imaging: ccalcification of cT, dark on T1, bright on T2
path: fried egg appearance
goals: prolongation of disease remission
outcome: 8-10 years with everything - will undergo malignancy
2 prognostic indicators of oligodendroglioma
- 1p/19q status
2. IDH mutation
what is effect of 1p/19q status
those with this deletion tend to do better
what is IDH mutation
enzyme mutation
- less NADPH
- creation of 2-HG metabolite, an onco metabolite
**4 what is outcome of infiltrative gliomas (WHO 2-4)
incurable
**5 what is presentation of low grade tumor
siezure rather than neuro deficit
