Female endocrine Flashcards
how many promordial follicles are began with and how many are viable
2 million - 50% viable
what is day 1 of cycle
first day of mense
what happens around day 6
follicle develops antrum and estrogen production begins - other atretic
what are layers of follicle from inside out
granulosa cells>basement>theca>surface epithelium
what are 2 main E producing layers
theca and granulosa
what happens at day 14
ovulation and corpus fills with blood (corpus hemoraggeum)
what happens if give more FSH during follicluar phase
get more ovulation
where does oocyte go?
hopefully into fimbria of fallopian tube
what happens to corpus
become corpus luteum and produces progesterone and estrogen
hormone responsible for antrum formation
FSH
hormone responsible for granulosa proliferation
FSH/E2
hormone responsible for E2 production
LH/FSH
hormone responsible for dev of corpus luteum
LH
what happens to E over cycle?
goes up until ovulation and then drops
what happens in thecal cell
LH-R>cAMP>cholesterol to andrstendione
what happens to androstenedione in theca
small amount turned to estradiol and most goes into granulosa
what happens to androstenedion in granulosa
FSH-R>cAMP>turns androstene to estradiol
how is estradiol bound
2% free
60% albumin
38%GBG/SHGB
what do prostoglandins do?
vasospasm
what does progestrone do?
blood vessels, decrease uterine contractions
what estrogen do?
endometrial growth, increase prog-r
what are E feedback loops in early/follicular phase
-ve to GnRH and FSH
+ve to granulosa cells
what happens to E feedback in late follicular and ovulation
becomes +ve GnRh and LH
what produces inhibin and what does it do
made by granulosa cells and -ve to FSH to prevent more follicles from forming
what does corpus luteum secrete
- est.
- progesterone
- inhibin
what happens when corpus luteum dies in late luteal phase
drop in E and progesterone
why does CL dies
downregulated LH which it needed to live
what does E do to female phenotype
promary sex char. and most secondary (breasts and fat)
what does androgens do to ladies
pubic and axillary hair growth
libido
