Female endocrine

Question 1

how many promordial follicles are began with and how many are viable

Answer 1

2 million - 50% viable

Question 2

what is day 1 of cycle

Answer 2

first day of mense

Question 3

what happens around day 6

Answer 3

follicle develops antrum and estrogen production begins - other atretic

Question 4

what are layers of follicle from inside out

Answer 4

granulosa cells>basement>theca>surface epithelium

Question 5

what are 2 main E producing layers

Answer 5

theca and granulosa

Question 6

what happens at day 14

Answer 6

ovulation and corpus fills with blood (corpus hemoraggeum)

Question 7

what happens if give more FSH during follicluar phase

Answer 7

get more ovulation

Question 8

where does oocyte go?

Answer 8

hopefully into fimbria of fallopian tube

Question 9

what happens to corpus

Answer 9

become corpus luteum and produces progesterone and estrogen

Question 10

hormone responsible for antrum formation

Answer 10

FSH

Question 11

hormone responsible for granulosa proliferation

Answer 11

FSH/E2

Question 12

hormone responsible for E2 production

Answer 12

LH/FSH

Question 13

hormone responsible for dev of corpus luteum

Answer 13

LH

Question 14

what happens to E over cycle?

Answer 14

goes up until ovulation and then drops

Question 15

what happens in thecal cell

Answer 15

LH-R>cAMP>cholesterol to andrstendione

Question 16

what happens to androstenedione in theca

Answer 16

small amount turned to estradiol and most goes into granulosa

Question 17

what happens to androstenedion in granulosa

Answer 17

FSH-R>cAMP>turns androstene to estradiol

Question 18

how is estradiol bound

Answer 18

2% free
60% albumin
38%GBG/SHGB

Question 19

what do prostoglandins do?

Answer 19

vasospasm

Question 20

what does progestrone do?

Answer 20

blood vessels, decrease uterine contractions

Question 21

what estrogen do?

Answer 21

endometrial growth, increase prog-r

Question 22

what are E feedback loops in early/follicular phase

Answer 22

-ve to GnRH and FSH

+ve to granulosa cells

Question 23

what happens to E feedback in late follicular and ovulation

Answer 23

becomes +ve GnRh and LH

Question 24

what produces inhibin and what does it do

Answer 24

made by granulosa cells and -ve to FSH to prevent more follicles from forming

Question 25

what does corpus luteum secrete

Answer 25

1. est.
2. progesterone
3. inhibin

Question 26

what happens when corpus luteum dies in late luteal phase

Answer 26

drop in E and progesterone

Question 27

why does CL dies

Answer 27

downregulated LH which it needed to live

Question 28

what does E do to female phenotype

Answer 28

promary sex char. and most secondary (breasts and fat)

Question 29

what does androgens do to ladies

Answer 29

pubic and axillary hair growth

libido