pathology Flashcards
6 ways to classify cardiac patho
- failure to pump
- obst. of blood
- from or to heart - regurgitatn blood flow
- shunted blodd
- disorders of conduction
- rupture of heart or main vessels
6 ways to classify cardiac patho
- failure to pump
- obst. of blood
- from or to heart - regurgitatn blood flow
- shunted blodd
- disorders of conduction
- rupture of heart or main vessels
- what is failure of the heart pump
usually due to weak contractions of the cardiac muscle or may be due to stiffness of the vent. wall
- often end stage to a process
- lack of blood pumpin
what is cardiomyoapathy
heart disease resulting from abnormality of the myocardium
- can be primary (genetic) or secondary due to disease
what is initial adaptation to heart failure
- increase end diastolic volume
- activate SNS
- activate RAAS
- hypertrphy
what is issue with hypertrophy
increase in size of myocytes, but not more caps
- means it’s vulnerable to decompensation
what happens to fluid hemodynamics in heart failure
- incr. capillary hydrostatic press or decrease eplasm oncotic press
- edema - fluid can collect in other cavities
5 causes of edema
- increase hydrostatic P
- CHF - reduced plasma oncotic P
- nephrotic syndrome - lymph obst
- Na retention
- inflammation
3 types of edema in order of baddness
- subcut.
2 pulmonary - cerebral
- obstruciton to blodd flow (2 forms)
- can’ t get through heart
2. can ‘t get too heart
casues of poor flow through the heart
problems with valves
- stenosis, calcification
causes of problems of blood to heart
obstruction of coronary As
- plaque or occlusion
»> ischemia
triad of thrombus formation from most to least important
- endothelial injury
- low flow
- hypercoag
what cause of endothelial injury
esp. at sites of plaques or previous injuries
what is issue with abnormal blood flow
normal flow is laminar
- turbulence
- contact with walls - statis
- clotting
2 main causes of hypercoag
primary
- genetcs
secondary
- smoking, OCP, preg, immobil
2 ways to classify thrombus
- A or V
2. occlusive or partial
4 possible fates of a thrombus
- propagation - bigger
- embolization
- dissolution
- organization and recanalization
3 what is regurg blood flow
failure to maintain unidirectional blood flow
- valves can’t close properly and let blood back in
- main causes of shunted blood
typically cangenital that didn’t close
3 types of shunts
- L to R - PO or DA
- R to L - R pressure is higher
- malformation causing an obstruciton
- disorders of conduction
lots to come
- rupture of great vessels
usually due to trauma - leak out
5 causes of shock
- cardigenic - MI, rupture, tamponade
- hypovolemic
- fluid loss, hemmorage - sepsis
- neurogenic
- anaphylaxis
3 phases of shock
- initial non-prgressive
- able to maintain with neuro-humoral
- tachy, vasoconstirction - porgressive
- drop pH
- less vasomotor response
- organ begin to fail - irreversible
- low contraction
- leak of enzymes
- lyte disturbace
- toast