disorders of coag

Question 1

3 features of hemostasis

Answer 1

1. rapid
2. localized
3. regulated carefully

Question 2

3 steps to hemostais

Answer 2

1. primary - vessel clamp, plug fomation
2. secondary - fibrin clot
3. resolutions - fibrinolysis

Question 3

3 As of hemostasis

Answer 3

1. adhesion
2. activation
3. aggregation

Question 4

most important test of hemostasis

Answer 4

bleeding Hx

Question 5

2 types of bleeding Hx

Answer 5

1. inherited - lifelong/ family Hx

2. acquired - meds, illness

Question 6

what happens in surface cuts in primary vs secondary hemostasis

Answer 6

1. exxcessive

2. normal

Question 7

onset after injury in primary vs secondary hemostasis

Answer 7

1. immed.

2. delayed

Question 8

site in primary vs secondary hemostasis

Answer 8

1. superficial

2. deep

Question 9

3 causes of primary hemostasis probs.

Answer 9

1. blood vessels
2. von Willebrand disease
3. platelet probs - quant or quality

Question 10

what happens in vW disease

Answer 10

no VWF - no collagen binding

Question 11

3 causes of thrombocytopenia

Answer 11

1. dec. production
2. sequestration
3. incr. destruction

Question 12

3 places platelets can go wrong in primary

Answer 12

1. adhesion
2. activation
3. aggregation

Question 13

how activation problems are caused

Answer 13

drugs that block platelet activation - don’t expose glycoproteins on platelet surface

Question 14

problems with platelet aggregation

Answer 14

don’t have GP 2b/3a - don’t bind to each other

Question 15

way to look at the intrinsic vs. extrinisic paths

Answer 15

1. extrinsic - on/off switch

2. int. volume switch

Question 16

test to check if ext. pathway is working

Answer 16

PT (prothrombin time)

Question 17

test to check if intrinsic pathway is working

Answer 17

PTT (partial thromboplastin time)

Question 18

what does hemophlia A effect

Answer 18

no factor VIII

Question 19

cause of hemo A

Answer 19

X linked reccesive

Question 20

3 acquired of disorders of hemostasis and factor affected

Answer 20

1. Vit K - II, VII, IX, X
2. liver disease - all but VIII
3. DIC - all but VIII

Question 21

Vit K dependant factors

Answer 21

10, 9, 7, 2 and anticoag C and S

1972, canada vs. soviets

Question 22

why liver diease affects

Answer 22

all factors but 8 made in liver

8 is made in endothelium

Question 23

what happens in DIC

Answer 23

widespread systemic activation of coag. > overwhelms the system and uses all the factors up

Question 24

3 types of venous thromboebolic disease and where

Answer 24

1. pulmonary emobolis
2. DVT - legs
3. superficial thrombophlebitis - superficial veins