disorders of coag Flashcards
3 features of hemostasis
- rapid
- localized
- regulated carefully
3 steps to hemostais
- primary - vessel clamp, plug fomation
- secondary - fibrin clot
- resolutions - fibrinolysis
3 As of hemostasis
- adhesion
- activation
- aggregation
most important test of hemostasis
bleeding Hx
2 types of bleeding Hx
- inherited - lifelong/ family Hx
2. acquired - meds, illness
what happens in surface cuts in primary vs secondary hemostasis
- exxcessive
2. normal
onset after injury in primary vs secondary hemostasis
- immed.
2. delayed
site in primary vs secondary hemostasis
- superficial
2. deep
3 causes of primary hemostasis probs.
- blood vessels
- von Willebrand disease
- platelet probs - quant or quality
what happens in vW disease
no VWF - no collagen binding
3 causes of thrombocytopenia
- dec. production
- sequestration
- incr. destruction
3 places platelets can go wrong in primary
- adhesion
- activation
- aggregation
how activation problems are caused
drugs that block platelet activation - don’t expose glycoproteins on platelet surface
problems with platelet aggregation
don’t have GP 2b/3a - don’t bind to each other
way to look at the intrinsic vs. extrinisic paths
- extrinsic - on/off switch
2. int. volume switch
test to check if ext. pathway is working
PT (prothrombin time)
test to check if intrinsic pathway is working
PTT (partial thromboplastin time)
what does hemophlia A effect
no factor VIII
cause of hemo A
X linked reccesive
3 acquired of disorders of hemostasis and factor affected
- Vit K - II, VII, IX, X
- liver disease - all but VIII
- DIC - all but VIII
Vit K dependant factors
10, 9, 7, 2 and anticoag C and S
1972, canada vs. soviets
why liver diease affects
all factors but 8 made in liver
8 is made in endothelium
what happens in DIC
widespread systemic activation of coag. > overwhelms the system and uses all the factors up
3 types of venous thromboebolic disease and where
- pulmonary emobolis
- DVT - legs
- superficial thrombophlebitis - superficial veins
