Lung growth and defense Flashcards
what rotates gut in development
cilia
where does gas ex happen at birth
alveolar ducts
age at which all alveoli are grown in # and size
8 and 15
what causes infant resp distress syndrome
surfactant defiency
what causes bronchopulmonary dysplasia
intubation/ventilation
are the lungs really sterile?
no, there is lots of unculturable bacteria
2 types of aquired lung defences
- humoral def.
2. pulmonary microbionme
4 functions of the nose
- warm/humidifies
- remove large particles
- anitoxidant
- absorbs soluble pollutnats
2 ways infections happen
- inspiration
2. aspiration
what normally prevents aspiration
epiglottis and vocal cords closing
3 causes of normal mechs. of aspiration prevention to fail
- depressed CNS
- muscle weakness
- esop disorders
what causes aspiration
infections caught in muscus and pulled into the lung
what sizes of particles get stuk where
> 8u get filtered out
2-4u are perfect to land in alveoli
size of bacteria and cig. particles
4u
what initiates a cough
particles touch upper airway and vagus sends signal
how is velocity increased in cough
high expiratory flow through a smaller trachea area
3 ways to fuck the cough reflex
- narcotics
- decrease (abdo) muscle strength
- airway obstruction
what are 2 layers of mucus and where produced?
- sol (bottom) - by goblets
2. gel (top) - mucus glands
what happens in CF
Na/Cl transport deficiency leads to think mucus
where do alveolar macrophages come from
blood monocytes
what happens in AIDS
lack of immunity leads to recurrent lung infections
what does one potentially lose in C-sections
aquired microbiome from mother
