Pre-eclampsia, fetal growth restriction, and stillbirth Flashcards
1
Q
6 hypertensive disorders of preg
A
- Gestational Hypertension – blood pressure elevation after 20 weeks of
gestation that is asymptomatic and not associated with proteinuria - Chronic hypertension – blood pressure elevation that predates
pregnancy (or may be first discovered in early pregnancy) - Pre‐eclampsia – new‐onset hypertension (generally) after 20 weeks of
gestation, accompanied by proteinuria, OR features of severe disease - Chronic Hypertension with super‐imposed pre‐eclampsia
- HELLP Syndrome – Hemolysis, Elevated Liver enzymes, Low Platelets
- Eclampsia – Encephalopathy associated with severe pre‐eclampsia
characterized by grand mal convulsions
2
Q
features of pre-eclampsia
A
new onset HT+ protenuira OR thrombopenia liver enzymes renal impariment
3
Q
4 systems affected by pre-eclmpsia
A
- fetus
- renal
- liver
- brains
4
Q
factors that increase preEC risk
A
– Advanced Maternal age – High BMI – Elevated BP – PV bleeding >5days in 1st trimester – Pre‐conception relationship
5
Q
3 factors that reduce risk
A
- smokingin T1
- misscarriage same partner
- attempt to conceive >12Mo
6
Q
what is perfect placenta
A
disc with cord in middle and vessels all around
7
Q
4 tests to consider
A
- maternal characerisitics
- IPS biochem
- morphology
- uterine artery doppler
8
Q
what does multiply abnormal IPS indicate
A
75% PPV for preterm
9
Q
what is bad morphology
A
small thick and with areas of poor development
10
Q
what is placental insufficiency
A
chorion regression - doesn’t grow around the cord
11
Q
what does doppler help indicate
A
uteroplacental insufficiency
12
Q
what is s-FLT1
A
- anti-angiogenic protein
- released from synsytio and contributes to maternal endothelial dysfunction - less angiogeneiese and more vasoconstiction
13
Q
what does low PIGF indicate
A
low time to delivery
14
Q
what to do in severe pre-eclmp or later in time
A
deliver
15
Q
what is importance of eclampsia
A
1 killer in low resource settings
