Seminar

Question 1

What is donepezil and what is it for

Answer 1

Acetylcholinesterase inhibitor - may be good for cognitive functions

Question 2

issues to consider with B-blockers

Answer 2

1. selectivity - watch for bronchoconstriction
2. lipid solubility - propranolol hits the brain more easily and has CNS effects
3. onset and duration
4. elimination pathways (liver/renal)

Question 3

what does diltiazem do to enzymes

Answer 3

inhibitor of CYP3A4/5

Question 4

what does cannabis act on

Answer 4

CB1 and CB2 - GPCR i/o pathways

Question 5

indications for sativex

Answer 5

1. MS spacticity

2. adjunctive analgesic in severe cancer pain

Question 6

indications for nabilone

Answer 6

antiemetic

Question 7

what is normal acetominephen path

Answer 7

phase 2 glucouronidation and sulfation with a little CYP to NAPQI

Question 8

what is acetominiphen antidote

Answer 8

N-acteyl-cystene - bind to NAPQI and prevents damage

Question 9

what does clarytrhropycin do to digoxin

Answer 9

inhibs PGy and so don’t push as much out

Question 10

what is anion gap

Answer 10

Na-Cl-HCO3 – should be under 12 – if not, added an anion

Question 11

what is osmolar gap

Answer 11

OSM - (2xNA) - Glucos - BUN

Question 12

why is ethylene glycol toxic

Answer 12

it isn’t, but will be biotransformed to toxic metabolites

Question 13

what is antidote to ethylene glycol toxicity

Answer 13

fomipezole or ethanol – compete for the alocohol dehydrogenase