hematopoesis

Question 1

location of hematopoesis in embryo, fetus, adultq

Answer 1

embryo - yolk sac
fetus - liver
adult - marrow and thymus

Question 2

location of HP in child vs. adult

Answer 2

child - full skeleton

adult - axial skelton

Question 3

2 options of HSC division

Answer 3

1. self-renewal

2. differentiation

Question 4

location of HSCs in marrow and actitivty

Answer 4

1. endosteal (surface) - resting

2. endothelium (vascular) - active

Question 5

what can mobilize and HSC

Answer 5

growth factor (G-CSF)

Question 6

creation of first div of HSC

Answer 6

blasts

Question 7

normal volume of blasts

Answer 7

<5% , over 20% = leukemia

Question 8

function of erythroprotein (Epo)

Answer 8

promotes RBC differntiation

Question 9

location of Epo production

Answer 9

kidney

Question 10

feedback loop of Epo

Answer 10

hypoxia>incr. Epo>inrc RBC>normoxia>stop production

Question 11

order if platelet differentiation

Answer 11

thrombopoiten>megakaryocytes>little bytoplasm packages that break off

Question 12

platelet equivalent to epo and location of production

Answer 12

Tpo - liver

Question 13

consequences of thombocythemia

Answer 13

blood clots - thrombosis

Question 14

Path of WBC homeostasis

Answer 14

infection>macrophages stim CSF>bone marrow>more WBCs

Question 15

define pancytopenia

Answer 15

all cell counts low - bone marrow probs

Question 16

Causes of bone marrow failure (3)

Answer 16

1. marrow destruction
2. marrow malfunction
3. marrow infiltration (ie leukemia)

Question 17

3 consequences of bone marrow failure

Answer 17

1. anaemia
2. thrombocytopenia - bleeds
3. leukopenia - infections