Fatty liver

Question 1

4 posssible effects of alcolhol on the liver

Answer 1

1. nothing - most common
2. fatty liver
3. alc hepatitis
   4, alc. cirrhosis

Question 2

feat. of fatty liver

Answer 2

• large fat drops in hepatocytes
• livre can be enlarged
• AST>ALT

Question 3

feat. of alc. hepatitis

Answer 3

• acute inflammatory syndrome, usually on top of chronic damage
• often occurs after binge
• can resolve if stop drinking

Question 4

2 diagnostic clues the hepatitis

Answer 4

1. AST>ALT

2. Hx is key

Question 5

mgmt of hepatitis

Answer 5

no booze

• vitamins
• watch for withdrawal

Question 6

feat. of cirrhosis

Answer 6

• risk for liver failure

- need to be alc free for >6 mon

Question 7

risks of social drinking

Answer 7

• low risk of chronic damage

- high risk of social issues

Question 8

risk iof chronic consumption

Answer 8

• small amoiunts may have health benefits

- higher levels risk liver injury

Question 9

what is seen in path

Answer 9

1. fat droplets in hepatocytes
2. fibrosis forms in zone 3 around the central vein
3. mallory bodies form in hepatocytes and may attract neutrophils

Question 10

feat. of NAFLD

Answer 10

• identical to alc. fatty liver
• assoc wtih metabolic syndrome
• excludes other causes

Question 11

2 hit patho of fatty liver

Answer 11

1st - TG accumulations - steatosis

2nd - inflammation and destruction - cellular stresses - steato hepatitis

Question 12

ppl at risk for NAFLD (4)

Answer 12

• metabolic
• rapid weight loss
• abdo aurg
• drugs or toxins

Question 13

things to look for

Answer 13

• no diagnostic test
• ALT>AST
• metabolic
• exclude other causes
• ferritin can be very high