Anti arrhythmics Flashcards
what is an AArr
something that reduces or prevents the occurance of an arr
**4 classes of AArrs and their electrophysical action
- Block Na channels - slow conduction velocity
- block B receptors - anti-andrenergic effects
- K channel blocker - prolonged action potential duration
- Ca channel blocker - heart rate slowing and slower AV nodal conduction
what are the 3 grades of refractory periods
- absolute
- partial
- effective
what are 3 types of class 1 actions
A - slows depol and repol - increased QRS and QT
B - shortens repol - lower QT
C - slows depol - increased QRS
what is most common cause of arr
reentry - block on one side means can come back around again and depolarize
2 ways to prevent reentry
- slow conduction
2. slow repolarization
***2 disease were AArrs are most commonly used
- Afib/flutter or tachycardia
2. in PTs with ICD to prevent vent. tachy
what is only drug to stop vent fib
bretylium
potential alternative method of assessing outcomes that %AFib free
patient response (happy)
what is quinidine and what is it for?
1a - primary arr
what is procainamide and what is it for?
1a - VT
what is flecainide and what is it for?
1c - Afib
what is sotalol and what is it for?
2 - VT, Afib
what is amiodarone and what is it for?
3 - all arrs
what are risks for each class of AArr drugs
- sudden death (VT of VF)
- fatigue, bradycard
- torsades de pointes VT, sudden death
- worsening heart failure, brady
