cardiac meds Flashcards
1
Q
4 major athero targets for drugs
A
- large lipid core
- lower chol.
- reduce inflammation - thin fibrous cap
- stabilize - endothelium
- inprove function - thrombus
- anti-platelet
- anti-coag.
2
Q
target of a statin
A
inhibit acteyl CoA, so can’t synthesize chol.
3
Q
effects of statins on LDL
A
atorvastatin - 40-50%
rosuvastatin - 50-60%
4
Q
4 other chol. drugs and their effects
A
- Cholestramine - resin - 20-30
- ezetimibe - block GI absorb - 20
- ibrates - 20
- niacin - 30, also raises HDL
5
Q
what is new lipid drug
A
PCSK9 inhibitor
- don’t break down LDL-r, so pull in more to the liver
- another 50% reduciton
6
Q
3 main targets to stop platelet activation
A
- ADP
- COX
- fibrinogen
7
Q
main COX blocker for the heart
A
ASA
8
Q
ASA effects
A
less strokes and coronary events
9
Q
what are ADP blockers (4)
A
1 .clopidigrel
- ticlopidine
- ticagrelor
- prasugrel
10
Q
what is effect of ADP blockers
A
more effective than ASA, but more expensive too
11
Q
what are GP2b/3a inhibs
A
abciximab to stop final step of platelet aggregation
12
Q
what are 2 old anti-coags and what did they do
A
- warfarin - blocks 10a
2. heparin - blocks thrombin
13
Q
issues with old ones
A
- hard to dose
- need monitoring
14
Q
new option to heparin
A
LMWH - fractionated
- dose is clear
15
Q
what are new oral anti-coags
A
- apixaban and rivaroxiban
- both with in 10a - dabigatran
- works on thrombin
