asthma Flashcards
2 extra function of lung vessels
- filter out infections
2. act as reservoir for extra blood
what is hereditary hemorrhagic telantectagia
arteries connect to veins without hitting microscirculation
what is likely cause of HHT
TGF-beta system
what produces surfactant
type 2 pneumocytes
treatment of lack of sufactant
corticosteroids in utero
what happens if too much surfactant
pulmonary alveolar proteinosis
what can help with pulmonary hypertension
NO - vasodilate to match perfusion to ventilation
what does a1 antitrypsin do, and what happens if missing?
protease inhibitor - if not, get proteases and breaks down elastase– early emphysema
2 methods of lung infection defence
- bronchus lymphoid tissues
2. alveolar macrophages
what does immunity development depend on?
whether we are expose to bacteria
3 other functions of biome
- diabetes and obesity
- gut health
- replacement of bad bact. by good
what defines asthma as a SYNDROME
- bronchospasm
- mucous hypersecretion
- epithelial desquamination
- airway inflammation
what is a pulmonary dendritic cell
small sub-endothelial cell
antigen presenting
what are 2 lung lymphocyte cell types and fucntions
- Th1 - regulate immunity
2. Th2 - active in allergic disease
which lymphocyte dominates in childhood
Th1 - infections
