early childhood path Flashcards

1
Q

major cause of death in 1mo t0 12mo

A

SIDS - 1/2 of death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

def. sudden unexpected death

A

instant death occurring within 24hrs of onset of Sx under 12months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

def. SIDS

A

sudden unexpected death with death occuring in sleep and cause remains unknown even after investigations including autopsy and clinical Hx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is cause of SIDS

A

unknown - diagnosis of exclusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

peak of SIDS

A

1-4 mos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

major SIDS intervention

A

sleep in back

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

risk factors for SIDS

A
  1. prone or side sleep
  2. soft bedding
  3. maternal smoking
  4. overheating
  5. late or no prenatal care
  6. young mom
  7. premature
    8 . male
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

3 genetic factors

A
  1. cardiac ion channel defects
  2. neurotransmitter assoc. defects
  3. complement C4 defects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

5 common path findings in SIDS

A
  1. thoracic petechiae
  2. pulm congestion and edema
  3. mild resp inflammation
  4. mild brain swelling
  5. empty bladder
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is ontario system for investigation

A

MD coroner system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

3 parts to pre-autopsy

A
  1. scene investigation
  2. circ. of death
  3. infant and fam. medical Hx
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

steps to autopsy (7)

A
  1. external exam
  2. photograph
  3. diagnostic imaging
  4. complete internal exam
  5. detailed neuro exam
  6. microscopic exam
  7. microbio/chemical tests
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

6 other causes of SUID

A
  1. infection
  2. CNS disorder
  3. asthma
  4. CV
  5. metabolic
  6. GI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

def. cholestasis

A

reduction in bile formation or bile flow resulting in accumulation of bile - bilirubin - jaundice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

features of infant jaundice

A
  • yellow discoloration in sclera, skin, internal
  • pale stool
  • dark urine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what level is needed to cause jaundice

A

2-3 in adults, over 5 in infants

17
Q

what is physiologic jaundice

A

unconjugated bulirubinemia in infacnts - up to 15%

18
Q

def. kernicterus

A

deposition of bilirubin in basal ganglia - neuro impariment

19
Q

*** top 3 causes of early infant cholestais

A
  1. biliary atresia
  2. idiopathic neonatal hepatitis
  3. A1-antitrypsiin def.
20
Q

3 steps to investigate

A
  1. biochem - unconjugated?
  2. diagnotic imaging
  3. liver biopsy
21
Q

def. biliary atresia

A

pregressive necrotizing infalmmatory process affecting the extrahepatic biliary system
- loss of bile duct patency

22
Q

2 main forms of atresia

A
  1. perinatal form (80%) - forms later

2. fetal form (20%) - from birth

23
Q

causes of two forms

A

perinatal - progressive destruction of bilairy system

fetal - abnormal dev. of biliary system

24
Q

3 patho types of biliary atresia

A
type 1 and 2 - limited to ductal system below porta hepatis
type 3 (90%) - involves porta hepatis and ducts
25
Q

what happens to liver in atresia

A

damage due to bile backup

26
Q

3 types of imaging for atresia

A
  1. ultrasound
  2. HIDA scan
    3 operative cholangiogram
27
Q

what is needed for atresia diagnosis

A

liver biopsy

28
Q

3 treatments of atresia

A
  1. resection and reconstruction of part involved
  2. kasai procedure
  3. liver transplant
29
Q

what is kasai

A

loops of bowel anastamosed to porta hepatis

- high failure rate after 1 year