pharma of adrenal corticosteroids Flashcards
function of mineralcorticoids (3)
- conserve Na and H2O
- ionic balance
- blood volume and pressure
fucntions of glucocorticoids (4)
- metabolic effects
- brain and behaviour
- endocrine systems
- immune system
how does cortisol work
- bound to CBG
- passes membrane to bind receptor
- binds to DNA and changes transcription
- altered cells function follows
what are 3 mechanisms of cortisol
- release of protein kinase from cytosolic receptor
- membrane effects
- receptor mediated membrane effects
what does HSD2 do?
dehydoxylates cortisol to make cortisone
what are spironolactone and eplerenone
MC antagonsits
what do they treat
primary and secondary hyperaldosteronism - edem a and hypertension
what are advantages of aldosterone and cortisol analogs
- longer acting and more potent
2. separate CG and MC componentns
what is GC:MC ratio of prenisolone compared to cortisol
4:0.3
what is GC:MC ratio of fludrocortisone compared to cortisol
10:250
what is GC:MC ratio of dexamethosone compared to cortisol
25:0
what is specific about cortisone and prednisone
both need to be converted in body
what is adv of cortisone and prednisone
can be given orally
what are clinical uses of adrenal homones
- replacement therapy (adrenal insuff., CAH)
- antiinflammatory - antiallergy
- Cancer treatement
what are drugs used in replacement treatment
- hydrocortisone 15-20 mg/day
2. fludrocortisone 3-4mg/day
