SI Lec - Lymphatic System Flashcards
lymphatic system consists of
lymphatic vessels
lymphoid tissues
lymphoid organs
– activation of immune cells
lymphoid organs
counterpart of blood vessels; channels for lymph fluid
lymphatic vessels
results if system blocked or surgically removed
Edema
Terminal points of veins and arteries
Lymph capillaries
Have one way minivalves allowing excess fluid to enter but not leave
Lymph capillaries
Picks up bacteria and viruses as well as proteins, electrolytes and fluid
Lymph capillaries
Absent from bone, bone marrow, teeth, CNS
Lymph capillaries
Lymph capillaries are absent from (4)
Bone, BM, CNS, teeth
Similar to blood vessels (3 layers), but thin & delicate
lymphatic collecting vessels
Superficial lymphatic collecting vessels in skin travel with ___
superficial veins
Deep lymphatic collecting vessels of trunk and digestive viscera travel with deep arteries
deep veins
pressure in lymphatic collecting vessels
very low
distinctive appearance of lymphatic collecting vessels seen in __
lymphangiography
Lymphatic collecting vessels
drain into
lymph nodes
type of lymphoid organ, for production and maturation of lymphocytes
primary lymphoid organs
type of lymphoid organ, for differentiation and activation of lymphocytes
secondary lymphoid organs
primary lymphoid organs
Bone Marrow
Thymus
secondary lymphoid organs
MALT (Mucosa Associated Lymphoid Tissue)
Tonsils
Appendix
CALT (Cutaneous Associated Lymphoid Tissue)
-standby areas for immunocompetent lymphocytes (waiting for Ag encounter)
secondary lymphoid organs
Largest tissue of the body
Bone marrow
Produce all blood cells
Bone marrow
total weight of BM
1300 - 1500 g (adult)
Main source of hematopoietic tissue
BM
Center for Ag-independent lymphopoeisis
BM
Give % of B, T, NK cells in peripheral blood
In peripheral blood , B cells= 20% T cells= 61-89%, NK cells=22%
Where T cells develop their identity
thymus
Small, flat, bilobed organ found in the thorax, right below the thyroid gland and overlying the heart
thymus
mass of thymus at birth
30 g
mass of thymus at puberty
35 g
region of thymus where surface Ags are acquired
CORTEX
region of thymus
where T lympho are released
Medulla
Where reproduction of lymphocytes occur (Ag dependent)
Secondary Lymphoid Organs
Largest secondary lymphoid organ
spleen
length of spleen in cm
12
weight of adult spleen
150 g
location of spleen
Upper-left quadrant of the abdomen
secondary lymphoid organ for large discriminating filter
spleen
secondary lymphoid organ for Pitting and culling
spleen
splenic tissue can be divided into
red pulp and white pulp
splenic tissue type which
destroys old RBCs; extravascular hemolysis (macrophage-mediated)
red pulp
splenic tissue type which contains the lymphoid tissue; for immunity
white pulp
PALS meaning
Periarteriolar Lymphoid Sheath
PALS contents
T cells
Primary follicles contents:
B cells
Marginal zones contents
dendritic cells (phagocytic or antigen-presenting cells)
eat cells with hidden Ag, unveil the Ag, and present it to lymphocytes.
Dendritic cells
superficial lymph nodes
cervical axillary inguinal
deep lymph nodes
tracheobronchial
aortix
iliac
drainage of Superior R 1/4 of body
right lymphatic duct
drainage of the rest of the body
thoracic duct
Central collecting points for lymph fluid from adjacent tissues
lymph nodes
main fxn of lymph nodes
Filtration and generation of B memory cells
Filtration and generation of B memory cells
lymph nodes
contents of cortex of lymph nodes
macrophages, B cells
primary follicle of lymph node cortex contains __
resting B cells
secondary follicle/germinal center of cortex contains __
Ag stimulated B-cells
Paracortex of lymph node contains
T cells, interdigitating cells/Ag-presenting cells
Medulla contains
T cells, B cells, MO, plasma cells
specialized MALT
Peyer’s patches
trap pathogens entering the respiratory and alimentary tracts
tonsils
once believed to be a vestigial organ
appendix
filter bacteria in digestive system
appendix
epidermis + lymphocytes
CALT
potential sites for contact wih Ag
Secondary lymphoid organs:
Aggregated lymphoid nodules
Peyer’s patches
contains About 40 follicles, 1 cm wide
peyer’s patches
found in the distal small intestine (ileum
peyer’s patches
peyer’s patches contains how many follicles and their width
About 40 follicles, 1 cm wide
peyer’s patches found where
distal S.I. (ileum)
