HEMA LEC - RBC Content and Distributions and Assoc Diseases

Question 1

Cells have the normal one-third clear, central pallor area

Answer 1

Normochromasia

Question 2

a. Central pallor area is greater than one-third the diameter of the cell

Answer 2

Hypochromasia

Question 3

MCH and MCHC usually decreased

Answer 3

Hypochromasia

Question 4

Often associated with microcytosis

Answer 4

Hypochromasia

Question 5

Seen in iron-deficiency anemia, thalassemias, anemia of chronic disease, sideroblastic anemia, myelodysplastic syndromes

Answer 5

Hypochromasia

Question 6

hypochromasia grading

Area of central pallor is one half of cell diameter

Answer 6

1+

Question 7

hypochromasia grading

Area of central pallor is two third of cell diameter

Answer 7

2+

Question 8

hypochromasia grading

Area of central pallor is three fourth of cell diameter

Answer 8

3+

Question 9

hypochromasia grading

Thin rim of haemoglobin

Answer 9

4+

Question 10

Variation in hemoglobin content showing a slight blue tinge when stained with Wright’s stain; residual RNA

Answer 10

Polychromasia

Question 11

Indicates reticulocytosis; supravital reticulocyte stain to enumerate

Answer 11

Polychromasia

Question 12

polychromasia indicates ____

Answer 12

reticulocytosis

Question 13

Usually slightly macrocytic

Answer 13

Polychromasia

Question 14

polychromasia grading

1%

Answer 14

Slight

Question 15

3% polychromasia grading

Answer 15

1+

Question 16

5% polychromasia grading

Answer 16

2+

Question 17

10% polychromasia grading

Answer 17

3+

Question 18

> 11% polychromasia grading

Answer 18

4+

Question 19

(term no longer used)

Current terminology is spherocyte; lacks a central pallor area

Answer 19

Hyperchromasia

Question 20

current terminology for hyperchromasis

Answer 20

spherocyte

Question 21

Stacking or “coining” patterns of erythrocytes due to abnormal or increased plasma proteins

Answer 21

Rouleaux

Question 22

May see excessively blue color to smear macroscopically and microscopically

Answer 22

Rouleaux

Question 23

Seen in hyperproteinemia, multiple myeloma, Waldenstrom

Answer 23

Rouleaux

Question 24

Waldenstrom

Answer 24

Rouleaux

Question 25

To confirm true rouleaux formation, ___________ is employed. A drop of NSS will disperse false rouleaux while true rouleaux remains INTACT

Answer 25

saline replacement

Question 26

saline replacement

Answer 26

Rouleaux

Question 27

Macroglobulinemia, and conditions that produce increased fibrinogen (chronic inflammation)

Answer 27

Rouleaux

Question 28

True rouleaux formation is determined in the ___ area of the peripheral smear.

Answer 28

thin

Question 29

Characterized by clumping of erhthrocytes with no pattern

Answer 29

Agglutination

Question 30

Occurs when erythrocytes are coated with IgM antibodies and complement

Answer 30

Agglutination

Question 31

Seen in cold autoimmune hemolytic anemia (cold agglutinin disease)

Answer 31

Seen in cold autoimmune hemolytic anemia (cold agglutinin disease)

Question 32

Warm blood to 37oC to correct a false low RBC and hematocrit, and false high MCHC (>37g/dL) when using an automated cell counting instrument.

Answer 32

Agglutination