pharmacokinetic features cholinomimetic drugs

Question 1

Rapidly hydrolyzed by cholinesterase (ChE); duration of action 5–30 s; poor lipid solubility

Answer 1

Ach

Question 2

Resistant to ChE; orally active, poor lipid solubility; duration of action 30 min to 2 h

Answer 2

Carbachol, Betanechol

Question 3

Not an ester, good lipid solubility; duration of action 30 min to 2 h

Answer 3

Pilocarpine

Question 4

Like pilocarpine; duration of action 1–6 h; high lipid solubility

Answer 4

Nicotine

Question 5

Alcohol, quaternary amine, poor lipid solubility, not orally active; duration of action 5–15 min

Answer 5

edrophonium

Question 6

Carbamate, quaternary amine, poor lipid solubility, orally active; duration of action 30 min to 2 h or more

Answer 6

neostigmine

Question 7

Carbamate, tertiary amine, good lipid solubility, orally active; duration of action 30 min to 2 h

Answer 7

physostigmine

Question 8

Carbamate, like neostigmine, but longer duration of action (4–8 h)

Answer 8

pyrodistigmine

Question 9

Organophosphate, moderate lipid solubility; duration of action 2–7 days

Answer 9

echothiophosphate

Question 10

Organophosphate, high lipid solubility; duration of action 7–30 days

Answer 10

parathion

Question 10

Direct acting drugs that have both action on muscarinic and nicotinic

Answer 10

Ach and carbachol

Question 11

A direact acting alkaloid drug that activates nicotinic receptors

Answer 11

Nicotine

Lobeline

Question 12

Spectrum of action of bethanecol

Answer 12

Muscarinic