Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Botany > SI LEC - Antigens > Flashcards

SI LEC - Antigens Flashcards

1
Q

macromolecules capable of triggering an adaptive immune response by inducing antibodies or sensitized T cells in an immunocompetent host.

A

IMMUNOGENS-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

substance that reacts with ab or sensitized T cells but may not be able to evoke an immune response

A

ANTIGENS-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

reasons why we respond to immunogens (3)

A

Nature of immunogen itself
Genetic coding of MHC molecules that must combine w/ an immunogen before T cells are able to respond
Immunogen processing and presentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

FACTORS INFLUENCING THE IMMUNE RESPONSE

A 
Age
Overall health
Dose
Route of inoculation
Genetic predisposition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

TRAITS OF IMMUNOGENS

A

The ability of immunogens to stimulate a host response depends on the ff:
Molecular size
Chemical composition and molecular complexity
Foreigness
Ability to be processed and presented with MHC molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Immunogen must have a MW of at least

A

10,000 daltons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The greater the MW, the ___ the immunogenecity.

A

more potent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MW of the best immunogens

A

Over 100 000 daltons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

are best immunogens based on complexity

A

Proteins and polysaccharides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which is more immunogenic, CHON or CHO

A

CHONS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

EX of nonimmunogenic based on complexity (3)

A

synthetic polymers
pure nucleic acids
lipids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

usual form of CHO

A

CHO are usually in the form of glycoproteins (Rh and Lewis ags), glycolipids (ABH antigens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ex of glycoproteins

A

Rh and Lewis Ags

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ex of glycolipids

A

ABH Ag

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Pure nucleic acids and lipids must be attached first to a _____ to be immunogenic

A

carrier molecule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

are used for artificial heart valves, elbow replacement, and other medical appliances.

A

Synthetic polymers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

_______ better immunogen for an animal than is material for from a related animal.

A

Plant proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Any lymphocyte that will ______ will be normally deleted,

A

react to self Ags

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

All ____ are considered immunogenic

A

non self

20
Q

how are Ags processed

A

enzymatic digestion

21
Q

Types of epitope

A

repeating copies or differing specificities
linear/sequential
conformational

22
Q

Molecular shapes or configurations that are recognized by B or T cells

A

EPITOPE

23
Q

Small part of an immunogen that is actually recognized in the immune response

A

EPITOPE

24
Q

w/ epitope of 6-15 aa

A

PROTEINS

25
Q

PROTEINS : w/ epitope of how many aa

A

6-15

26
Q

recognized both linear and conformational epitopes present on the surface of an immunogen.

A

B cells

27
Q

recognized epitope only as a part of the complex formed with MHC on the surface of antigen-presenting cells

A

T cells

28
Q

B cells recognized both ___ (what epitope types) present on the surface of an immunogen.

A

linear and conformational epitopes

29
Q

T cells recognized epitope only as ______ on the surface of antigen-presenting cells

A

a part of the complex formed with MHC

30
Q

Non immunogenic small substances that need to be complexed to larger molecules to be able to stimulate immune response

A

HAPTENS

31
Q

Hapten is able to react to abs, even w/o a carrier molecule.

TRUE or FALSE

A

TRUE

32
Q

Has a single determinant and cannot form cross-links w/ more than one antibody molecule that are necessary for precipitation or agglutination.

A

HAPTENS

33
Q

Why haptens cannot form crosslinks

A

Has a single determinant

34
Q

type of antigen

belong to the host, no immune response

A

Autoantigens

35
Q

type of antigen
from other members of the host’s species,
eg blood ags, ags in tx transplantation, can stimulate immune response

A

Alloantigens

36
Q

type of antigen
from other species
eg plant ag, animal ags, microbial ags

A

heteroantigens

37
Q

type of antigen
heteroags that exist in unrelated plants or animals but are either identical or closely-related in structure so that ab to one can cross react w/ ag of the other.

A

heterophile Ag

38
Q

types of antigen

A

autoAg
alloAg
heteroAg
heterophile Ag

39
Q

Substance administered w/ an immunogen that increases the immune response

A

adjuvant

40
Q

Acts by producing a local inflammatory response that attracts a large no. of immune cells to the injection site.

A

adjuvant

41
Q

Acts by prolonging the existence of immunogens in the area, increasing the effective size of the immunogen, and increasing the no. of macrophages involved in Ag processing

A

adjuvant

42
Q

Freunds’ Complete Adjuvants consists of (3)

A

mineral oil, emulsifier, and killed mycobacteria (0.5 mg/mL)

43
Q

are the only approved adjuvant for clinical use in US.

A

Aluminum salts

44
Q

disadv of Freunds Complete Adjuvants

A

Freunds’ CA: produces granuloma, or large tissue scars

45
Q

adjuvant not used in humans, for research only

A

Freunds Complete Adjuvant

46
Q

Aluminum salt: is incorporated in ___ vaccines

A

Hepa B

Botany (324 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions