Para Lec - Hemoflagellates Flashcards
Leishman-Donovan body
amastigote
leishmanial form
amastigote
crithidial form
epimastigote
trypanosomal form
trypomastigote
what constitues the kinetoplast
parabasal body
blepharoplast
old world cutaneous leishmaniasis
Leishmania tropica
also known as Oriental Sore
Leishmania tropica
also known as Aleppo button
Leishmania tropica
also known as Baghdad or Jericho boil
Leishmania tropica
Habitat of what leishmania:
endothelial cells of the skin capillaries
within cytoplasm of monocytes
Leishmania tropica
vector of Leishmania tropica
Phlebotomus
Pathology of what leishmania: localized cutaneous infection which give rise to a macule, then a papule, a raised lesion with depressed ulcerated center
Leishmania tropica
raised lesion with depressed ulcerated center
papule
characterized by dry lesions
Leishmania tropica
Also known as Espundia
Leishmania braziliensis
Also known as American mucocutaneous
Leishmania braziliensis
Also known as Bubas
Leishmania braziliensis
Also known as Chiclero ulcers
Leishmania braziliensis
Also known as visceral leishmaniasis
Leishmania donovani
characterized by Kala-azar
Leishmania donovani
characterized by Dum-dum
Leishmania donovani
characterized by black fever
Leishmania donovani
habitat of ?: mucocutaneous junctions
Leishmania braziliensis
habitat of ?: RES: liver, spleen, BM,
Leishmania donovani
pathology of ?: splenomegaly with associated severe anemia
Leishmania donovani
vector of Leishmania donovani
Lutzomyia and Phlebotomus
vector of Leishmania braziliense
Lutzomyia and Psychodopygus
– erosion of pinna of ear
Chiclero’s ulcer
erosion of nose bridge
Tapir Nose
– looks like M. leprae infection/leprosy
Cutaneous Oriental Sore
hemoflagellate without epimastigote stage
Leishmania spp
diagnosis of leishmania
cannot identify if acute or past infection
Intradermal test (Montenegro Skin Test)
diagnosis of leishmania
only Antibody is detected
Intradermal test (Montenegro Skin Test)
– recent infection
Presence of IgM
– past infection
Presence of IgG
– non-specific, for screening only, consists of formalin and a drop of serum
-look for gel formation or agglutination
Formal-gel test
(greater Ig =
infection
o Normal A/G Ratio –
high albumin
o – inverted A/G Ratio
-high globulin = strong indication of inflammation
Leishmania infection
TREATMENT of Leishmania
- Antimony compounds
- Amphotericin B
- Pentamidine
- Nifurtimox
infective stage to final host
promastigotes
infective stage to vector/ intermediate host
amastigote
diagnostic stage
amastigote