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Botany > SI LEC - Innate Immunity Part 2 > Flashcards

SI LEC - Innate Immunity Part 2 Flashcards

1
Q

Serum Amyloid A assoc with

A

HDL-Cholesterol

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2
Q

Apolipoprotein

MW = ??

A

11, 685 daltons

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3
Q

Normal circulating levels of SAA

A

30 µg/mL

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4
Q

Functions of SAA

A

Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol

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5
Q 
Series of serum proteins that are normally present
Major functions include:
	  opsonization
     chemotaxis
     cytolysis
A

Complement

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6
Q

complement Major functions include:

A

opsonization
chemotaxis
cytolysis

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7
Q

Mannose-Binding Protein also called

A

Aka mannose-binding lectin

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8
Q

Trimer
Acts as an opsonin
Ca-dependent

A

Mannose-Binding Protein

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9
Q

Recognize foreign CHO found on bacteria, yeasts, viruses, parasites

A

Mannose-Binding Protein

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10
Q

Activates C’, helps promote phagocytosis

A

Mannose-Binding Protein

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11
Q

Normal concentration = of MBP

A

10 µg/mL

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12
Q

Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___

A

emphysema

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13
Q

endogenous ENZ that degrade elastin and collagen

A

Elastase :

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14
Q

Major component of the alpha band in SPE

Plasma inhibitor of proteases released from WBC (eg. elastase)

A

Alpha1-antitrypsin

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15
Q

Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation

A

Alpha1-antitrypsin

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16
Q

Can also react w/ serine proteases triggering C’ cascade or fibrinolysis

A

Alpha1-antitrypsin

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17
Q

Regulates expression of pro-inflammatory cytokines

A

Alpha1-antitrypsin

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18
Q

An Alpha2- globulin

A

haptoglobin

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19
Q

MW of haptoglobin

A

100 000

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20
Q

Binds free hgb (released by intravascular hemolysis) irreversibly

A

haptoglobin

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21
Q

Hgb Haptoglobin complex cleared by

A

liver

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22
Q

haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR

A

drop

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23
Q

Normal plasma conc= 40 to 290 mg/dL what acute reactant protein

A

haptoglobin

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24
Q

haptoglobin Normal plasma conc

A

40 to 290 mg/dl

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25
Q

Unfolded CHONS __ in blood vessels

A

aggregate

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26
Q

plays a role in protecting kidneys from damage

A

haptoglobin

27
Q

prevents loss of iron

A

haptoglobin

28
Q

prevents oxidative damage of free hgb

A

haptoglobin

29
Q

Most abundant coagulation factor

A

fibrinogen

30
Q

Normal levels= 100 to 400 mg/dL

A

fibrinogen

31
Q

forms fibrin clots

A

Fibrinogen

32
Q

trimer

A

mannose-binding protein

33
Q

dimer

A

fibrinogen

34
Q

fibrinogen normal levels

A

100 to 400 mg/dl

35
Q

MW = 340, 000 daltons

A

fibrinogen

36
Q

MW of fibrinogen

A

340 000

37
Q

Increases the strength of the wound

A

Fibrinogen

38
Q

Promotes aggregation of RBCs

can increased risk of developing CAD

A

Fibrinogen

39
Q

Forms a clot; a barrier to prevent spread of microbes

A

Fibrinogen

40
Q

Stimulates endothelial cell adhesion and proliferation

A

Fibrinogen

41
Q

autosomal recessive genetic disorder

Co accumulates in the liver, brain, cornea, kidneys,

A

Wilson’s dx

42
Q

Acts as ferroxidase

A

Ceruloplasmin

43
Q

the principal Co-transporting protein in the human plasma

A

Ceruloplasmin

44
Q

MW= 132, 000 daltons

A

Ceruloplasmin

45
Q

Binds 90-95% copper found in the plasma

A

Ceruloplasmin

46
Q

help make neutrophils sticky and enhance adherence to endothelial cells

A

Selectins:

47
Q

movement thru blood vessel walls.

A

diapedesis

48
Q

NEUT form __ which squeeze thru junctions

A

pseudopods

49
Q

chem’l messenger that cause cells to migrate in a particular direction

A

chemotaxins

50
Q

Life span of neutrophil in the tx:

A

5 days

51
Q

w/ primary and specific granules
Capable of phagocytosis but not as efficient as neutrophil
Neutralizing basophils and mast cells
Killing parasites

A

Eosinophils

52
Q

vasoactive amine that contracts smooth muscle

A

Basophils

53
Q

immunoglobulin that binds to surface of basophil

A

IgE

54
Q

lifespan of basophils

A

few hours

55
Q

Basophils that have migrated to the tissues.

A

Mast Cells

56
Q

Largest in the peripheral blood

A

Monocytes

57
Q

granules of monocytes (6)

A 
peroxidase
ACP
arylsulfatase
beta-glucuronidase
lysozyme
lipase
58
Q

monocytes Stay in peripheral blood up to ?? hours

A

70

59
Q

as macrophage become monocytes, there is an increase in __

A

Increase in ER, lysosomes, and mitochondria

60
Q

w/ progressive cellular enlargement to b/w 25-80 um

A

tissue macrophage

61
Q

Long lived but slow in motility

A

monocytes

62
Q

Fxn: microbial killing, tumoricidal, intracellular parasites eradication, phagocytosis, secretion of cytokines, Ag presentation

A

monocytes

63
Q

main fxn of dendritic cells

A

Phagocytose Ag and present in T helper cells

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