SI LAB - Glossary 1 Flashcards
removal of antibodies from serum by addition of red cells that possess the corresponding surface antigen
absorption
antigen that is not genetically determined and is sometimes transient
acquired antigen
immunity generated by actual production of antibody by the host in the presence of foreign antigen
active immunity
normal serum constituents that increase in the presence of infection, injury, trauma to tissues
acute phase proteins
a substance that can increase the specific antibody production to, or the degree of sensitization against antigen by increasing its size or length of survival in the circulation
adjuvent
a substance (usually injected with an antigen) that improves the immune response, either humoral or cellular, to the antigen
adjuvent
attachment of one substance to the surface of another, in particular, attachment of antibody to specific receptors on a cell surface
adsorption
collection into clumps of the cells or particles distributed in a fluid
agglutination
antibody capable of causing agglutination with surface antigens
agglutinin
an antigen agglutinated or clumped by an agglutinin
agglutinogen
system for activating complement beginning at C3 and do not involve a serologic reaction
alternative complement pathway
substance in the blood and the lymph serving as one of the active component on the process of cytolysis, the other components being the complement and the cells with antibodies
amboceptor
anti-sheep red blood cell antibody that causes hemolysis of sheep red cells in the presence of complement
amboceptor
globulin formed in response to exposure to an antigen
antibody (Ab)
also known as immunoglobulin
antibody (Ab)
any substance that oppose or counteract the action of a complement
Anticomplementary susbtance
any substance which, when introduced into the body, stimulates the formation of antibody
Antigen (Ag)
union of antibody with its homologous antigen
Antigen-antibody complex
an autoantibody directed against a component of the nucleus, commonly found in systemic lupus erythematosus (SLE)
Antinuclear antibody (ANA)
serum containing antibody
antiserum
an antibody produced against streptolysin O,
antistreptolysin O
a hemolysin produced by Group A streptococci
antistreptolysin O
ASO meaning
antistreptolysin O
antibody produced against self antigen
autoantibody
a molecule that behaves as a self antigen
autoantigen
lymphocyte from the bursa of Fabricius or an immunoglobulin-forming cell
B-cell
substance contained in beef erythrocytes, which is capable of absorbing the heterophil antibodies produced as a result of infectious mononucleosis (IM) and serum sickness
Beef erythrocyte (BE) antigen
BE meaning
Beef erythrocyte
a protein, not normally present in human blood, appears in a wide variety of inflammatory conditions
C-reactive protein
characterized by their ability to react with the C-polysaccharide somatic substance of the pneumococci
C-reactive protein
the major system of complement activation that involves all nine components of complement and is initiated by a serologic reaction
Classic complement pathway
an agglutinin or hemagglutinin that is active at 4C but not at 37C
Cold agglutinin
a humoral mechanism of nonspecific immune response consisting at least 14 components that proceed in a cascading sequence of activation resulting in a cell lysis
Complement
fixation of binding of complement in a reaction with antigen and antibody
Complement Fixation
monitors day to day accurate performance of the laboratory tests/analyses
Control
a substance composed of extract from fresh beef hearts combined with lecithin and cholesterol
Cardiolipin Antigen
a hemagglutination test that defines the characteristics of heterophil antibody by guinea pig and beef cell antigens
Davidsohn Differential Test
most common procedure for the separation of mononuclear cells
Density gradient centrifugation
separation of one substance from the other
dissociation
a fluid medium containing antibodies deliberately removed from the red cells
eluate
ligand assay in which the label is an enzyme and the binding reagent is an antibody
enzyme immunoassay
point of dilution in a serologic reaction in which all the antigen and all the antibody are mutually involved in complexes
equivalence point
a specific type of precipitation that occurs over a narrow range of antigen concentration
flocculation
aggregation of colloidal particles in a serologic reaction
flocculation
heterophil antibody that is stimulated by one antigen and reacts with unrelated surface antigen present on cells from different mammalian species
forssman antibody
substance which absorbs the Forssman and serum sickness antibodies
Guinea pig kidney (GPK) antigen
flagellar antigens of bacteria
H antigens
agglutination or clumping of red blood cells by the antiserum
hemagglutination
attachment of antibody to specific receptors on a cell surface
adsorption
ANA meaning
antinuclear antibody
