HEMA Lec - Chapter 11

Question 1

Body iron content:

Answer 1

3-4 g

Question 2

iron compartments 70%

Answer 2

Hb

Question 3

iron compartments 25%

Answer 3

storage iron: ferritin & hemosiderin

Question 4

iron compartments 5%

Answer 4

myoglobin

Question 5

iron compartments

Answer 5

POD, Catalase
Cytochrome
Fiboflavin enzymes
Transferrin

Question 6

iron compartments 0.1%

Answer 6

serum

Question 7

Iron overload: due to

Answer 7

1. increased Fe absorption due to genetic predisposition 2. repeated transfusion

Question 8

Iron deficiency

Answer 8

Excessive bleeding

Inadequate intake

Question 9

Thus iron homeostasis is regulated by ____

Answer 9

adjusting iron intake

Question 10

mg iron are absorbed each day

Answer 10

1 – 2 mg

Question 11

iron absorption occurs where

Answer 11

duodenum and jejunum

Question 12

should be the form of iron so that it will enter the cell (enterocyte)

Answer 12

Fe +2 :

Question 13

sources of

Heme: Non-heme: from legumes, leafy veggies

Answer 13

from Hb; Mb and meat sources;

Question 14

sources of

Non-heme:

Answer 14

from legumes, leafy veggies

Question 15

Only?%of dietary iron absorbed

Answer 15

10%

Question 16

how is iron lost in the body [physiologic]

Answer 16

Cell loss: gut, desquamation
Menstruation (1mg/day)
Pregnancy, lactation

Question 17

Reduction Fe+++ to Fe++

Answer 17

DcytB (for non-heme iron)

Question 18

Transport into cell for non-heme iron

Answer 18

DMT1 (for non heme iron)

Question 19

Transport out Fe+2

Answer 19

Ferroportin

Question 20

Oxidizes Fe++ to Fe+++

Answer 20

Hephaestin

Question 21

: acted upon by heme oxygenase to free Fe+2

Answer 21

Hemin

Question 22

hepcidin meaning

Answer 22

Hepatic bacteriocidal protein

Question 23

Master iron regulatory hormone

Answer 23

hepcidin

Question 24

Inactivates ferroportin

Answer 24

hepcidin

Question 25

Stops iron getting out of gut cells

Iron lost in stool when gut cells shed

Answer 25

hepcidin

Question 26

Leads to decreased gut iron absorption

Answer 26

hepcidin

Question 27

decrease in stored iron in the macrophages and liver

Answer 27

hepcidin

Question 28

present on cell surface to release iron

Found on gut cells, liver cells and macrophages

Answer 28

Ferroportin

Question 29

TRANSFERRIN synthesized in ___

Answer 29

liver

Question 30

cofactors required by ferroportin

to oxidize iron to allow for binding to transferrin

Answer 30

Hephaestin in gut

Ceruloplasmin in other cells

Question 31

Transferrin gene is located in chromosome ____

Answer 31

3(long arm)

Question 32

Each molecule of transferrin binds can bind ___ Fe3+ molecules (oxidized)

Answer 32

2

Question 33

saturation of transferrin with Fe

Answer 33

30%

Question 34

Transferrin Contains __% of serum Fe.

Answer 34

95%

Question 35

Truncated form of cell surface receptors

Found in the circulation

Answer 35

Soluble Transferrin Receptors

Question 36

3 STORAGE SITES OF IRON

Answer 36

Liver
BM
Spleen

Question 37

high level of soluble transferrin receptors would mean iron deficiency or overload

Answer 37

deficiency

Question 38

= iron-binding sites w/c do not carry iron

Answer 38

Serum unsaturated iron-binding capacity

Question 39

ferritin binding up __ atoms of iron per molecule.

Answer 39

4,500

Question 40

A routine blood test – reflects iron stores

Answer 40

Ferritin

Question 41

Prussian blue can be used to stain (blue coloration) [3]

Answer 41

hemosiderin, siderocyte and sideroblasts

Question 42

retic in the BM with iron

Answer 42

Siderocytes

Question 43

normal is only 10%; these are the nucleated RBCs in the BM w/ iron

Answer 43

Sideroblasts

Question 44

Normally , mature RBCs must or must not contain iron?

Answer 44

must not