HEMA LEC 2 - MDs Classification

Question 1

BM

Unilineage dysplasia: ≥10% of cells in one myeloid lineage

Answer 1

RCUD

Question 2

PB
Unicytopenia*
No or rare blasts (

Answer 2

RCUD

Question 3

PB
Anemia
No blasts

Answer 3

RARS

Question 4

BM

≥15% of erythroid precursors are ringed sideroblasts Erythroid dysplasia only

Answer 4

RARS

Question 5

PB
Cytopenia(s)
No or rare blasts (

Answer 5

RCMD

Question 6

Dysplasia in ≥10% of cells in two or more myeloid lineages

neutrophil and/or erythroid precursors and/or megakaryocytes

Answer 6

RCMD

Question 7

– 5% to 9% blasts in BM/ 2% - 4% blasts in PB

Answer 7

RAEB-1

Question 8

-w/ Auer rods (regardless of blast count)

Answer 8

RAEB-2

Question 9

10% to 19% blasts in BM/

5% - 19% blasts in PB

Answer 9

RAEB-2

Question 10

Affects predominantly women

Answer 10

Myelodysplastic Syndrome with Isolated del(5q) (5q-syndrome)

Question 11

Refractory anemia w/o other cytopenias and/or thrombocytosis, hypolobulated megakaryocyte, erythroid hypoplasia

Answer 11

Myelodysplastic Syndrome with Isolated del(5q) (5q-syndrome)

Question 12

Are subtypes of MDS that initially lack the specific changes necessary for classification into other MDS categories

Answer 12

Myelodysplastic Syndrome, Unclassifiable

Question 13

Thalidomide analogue; effective in patients with isolated del(5q) and addit’l cytogenetic abnormalities

Answer 13

Lenalidomide (Revlimid) -