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Botany > SI LEC - Classes of Antibodies > Flashcards

SI LEC - Classes of Antibodies Flashcards

1
Q

Most abundant immunoglobin,

A

IgG

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2
Q

% IgG

A

75-80% of serum Ig

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3
Q

S and MW of IgG

A

7S, MW=150,000

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4
Q

Longest half life (23-25 days)

A

IgG

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5
Q

Half life of IgG

A

23-25 days

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6
Q

IgG which cross the placenta

A

IgG1, IgG3 and IgG4

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7
Q

IgG least efficient in crossing the placenta

A

IgG2

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8
Q

IgG most effective complement activator

A

IgG3:

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9
Q

IgG High affinity for FcR on phagocytic cells, good for opsonization

A

IgG1 and IgG3

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10
Q 
FUNCTIONS
Provide immunity to the newborn
Fix complement
Coating antigen (opsonization)
Neutralizing toxins and viruses
Participate in agglutination and precipitation
A

IgG

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11
Q

% IgM

A

5-10%

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12
Q

S and MW of IgM

A

19S, MW= 970,000

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13
Q

Shorter life span than IgG (about 10 days)

A

IgM

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14
Q

Pentameric version is secreted, Monomeric on B cell surface

A

IgM

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15
Q

IgM version in secretion

A

pentamer

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16
Q

IgM version in B cell surface

A

Monomer

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17
Q

5 monomeric units are held together by __ chains

A

J

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18
Q

More efficient than IgG in complement activation

A

IgM

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19
Q

Cannot cross the placenta

A

IgM

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20
Q

Antigen-induced conformational changes in IgM

(2)

A

starfish or planar

staple or crab

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21
Q 
FUNCTIONS
Complement fixation
Opsonization
Agglutination
Toxin neutralization
A

IgM

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22
Q

*First Ig of primary immune response

A

IgM

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23
Q

IgG increased at what response (primary or secondary)

A

secondary

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24
Q

conc of IgM in primary and secondary response

A

SAME

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25
Q

Long lag phase
Slow exponential increase in antibody
Short lived response

A

Primary Immune Response

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26
Q

Anamnestic response
Short lag phase
Antibody increase is more rapid
Long lived response

A

Secondary Immune Response

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27
Q

% IgA in serum IgG

A

10-15% of serum IgG

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28
Q

S and MW of IgA

A

7S and MW=160 000

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29
Q

Predominant Ig in secretions

A

IgA

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30
Q 
IgA Subclass
found in serum, mainly monomeric, polymers possible not common though
A

IgA1

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31
Q 
IgA Subclass
found in secretions, as dimer, w/ J-chain, w/ secretory component
A

IgA2

32
Q

IgA1 and IgA2: differ in __ aa (13 of which is located in the hinge region)

A

22

33
Q

__ more resistant to bacterial proteinases than IgG1

A

IgA2

34
Q

MW of IgA secretory component

A

70 000

35
Q

IgA Structure

attached to Fc region around the hinge of the alpha chain,

A

Secretory component

36
Q

IgA Structure

facilitates transport of IgA to mucosal surface,

A

Secretory component

37
Q

IgA Structure

masks sites that would be susceptible to protease cleavage

A

Secretory component

38
Q

not capable of C’ activation

A

IgA

39
Q

FUNCTIONS of Ig
Patrol mucosal surfaces
Neutralize toxins
Helps prevent bacterial adherence to mucosa

A

IgA

40
Q

extremely scarced in the serum (0.001%)

A

IgD

41
Q

% IgD in serum

A

0.001%

42
Q

half life of IgD

A

2-3 days

43
Q

MW of IgD

A

MW=180,000

44
Q

Expressed on B-cell Surface

- Play a role in B cell activation
- Regulate B cell maturation and differentiation
A

IgD

45
Q

Least abundant (0.0005%)

A

IgE

46
Q

% IgE

A

0.0005%

47
Q

S and MW of IgE

A

8S, MW=190,000

48
Q

Heat labile

A

IgE

49
Q

Nuisance ab

A

IgE

50
Q

Not capable of C’ fixation, agglutination, opsonization, or crossing the placenta

A

IgE

51
Q

Binds mast cells and basophils thru Fc(EPSILON)R (CH3)

A

IgE

52
Q

Binding causes degranulation (Histamine release)

A

IgE

53
Q

IgE Binds mast cells and basophils thru __

A

Fc(EPSILON)R (CH3)

54
Q

H chain genes are located on chromosome __

A

14

55
Q

kappa chain genes are on chromosome _

A

2

56
Q

the lambda chain genes are on chromosome __

A

22

57
Q

IgG with extra constant chain

A

IgG and IgM

58
Q

extra constant chain of IgG

A

CH2

59
Q

extra constant chain of IgM

A

CH3

60
Q

extra constant chain of IgG are sites for __

A

complement binding

61
Q

Ig implicated in HDN

A

IgG

62
Q

agglutination, nature of Ag

A

INSOLUBLE

63
Q

precipitation, nature of Ag

A

SOLUBLE

64
Q

conformation of IgM when unbound to Ab

A

Starfish

65
Q

conformation of IgM when bound to Ab

A

Crab

66
Q

patrol Ab

A

IgA

67
Q

protects IgA from enzymes that may degrade it

A

secretory component

68
Q

with polyIg receptor

A

IgA

69
Q

Ab diversity

different chromosomes control different parts of Ab

A

Tonegawa

70
Q

theory
1.) the lock and key concept of the fit of ab for ag 2.) the idea that an ag selected cell w/ built-in capacity to respond to it.

A

Ehrlich’s Side Chain Theory

71
Q

-individual lymphocytes are genetically pre-programmed to produce one type of Ig and that a specific antigen finds or selects those particular cells capable of responding to it, causing them to proliferate

A

Clonal Selection Theory

72
Q

3 Gene groups of HC genes

A

VH, D, J

73
Q

How many VH

A

39

74
Q

How many D

A

23

75
Q

How many J

A

6

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