BB LEC - ABO Blood System Part 3 Flashcards
1% to 8% of __ individuals produce anti-A1 in their serum, and
A2
22% to 35% of __ individuals produce anti-A1
A2B
A subgroup
has more antigenic sites for the H antigen thus giving(+) rxn w/ Anti-H lectin)
A2 CELL
A subgroup
(H antigen sites occupied by both A and A1 antigens
A1 CELL
small agglutinates w/in predominantly unagglutinated red cells
Mixed field agglutination:
The Bombay phenotype was first reported by ___ in 1952 in Bombay, India
Bhende
inheritance pattern of Bombay phenotype
autosomal recessive
defect in Bombay phenotype
which gene
mutation in FUT1 (H gene) and FUT2 gene
antigens of Bombay phenotype
none
genotype of Bombay
hh
enzymes in serum present in Bombay
A or B depending on ABO genotype
Is the Bombay phenotype secretor or not
nonsecretor
genotype w/c is least reactive with Anti-H
A1B
are those rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present.
para-Bombay phenotypes
Do Bombay and para-Bombay phenotypes have H enzymes
no
The genetic basis for the para-Bombays is (2)
a mutated FUT1 (H gene) with or without an active FUT2 gene (Se gene) or a silenced FUT1 gene with an active FUT2 gene.
- a rare group 1 discrepancy.
- presence of two cell populations in single individual like in cases of fraternal twins
CHIMERISM
when bacterial enzymes (of Proteus vulgaris) modify N-acetylgalactosamine into D- galactose)
ACQUIRED B phenomenon
ACQUIRED B phenomenon - when bacterial enzymes (of what bacteria?) modify N-acetylgalactosamine into D- galactose)
Proteus vulgaris)
