BB LEC - ABO Blood System Part 3

Question 1

1% to 8% of __ individuals produce anti-A1 in their serum, and

Answer 1

A2

Question 2

22% to 35% of __ individuals produce anti-A1

Answer 2

A2B

Question 3

A subgroup

has more antigenic sites for the H antigen thus giving(+) rxn w/ Anti-H lectin)

Answer 3

A2 CELL

Question 4

A subgroup

  (H antigen sites occupied by both A and A1 antigens

Answer 4

A1 CELL

Question 5

small agglutinates w/in predominantly unagglutinated red cells

Answer 5

Mixed field agglutination:

Question 6

The Bombay phenotype was first reported by ___ in 1952 in Bombay, India

Answer 6

Bhende

Question 7

inheritance pattern of Bombay phenotype

Answer 7

autosomal recessive

Question 8

defect in Bombay phenotype

which gene

Answer 8

mutation in FUT1 (H gene) and FUT2 gene

Question 9

antigens of Bombay phenotype

Answer 9

none

Question 10

genotype of Bombay

Answer 10

hh

Question 11

enzymes in serum present in Bombay

Answer 11

A or B depending on ABO genotype

Question 12

Is the Bombay phenotype secretor or not

Answer 12

nonsecretor

Question 13

genotype w/c is least reactive with Anti-H

Answer 13

A1B

Question 14

are those rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present.

Answer 14

para-Bombay phenotypes

Question 15

Do Bombay and para-Bombay phenotypes have H enzymes

Answer 15

no

Question 16

The genetic basis for the para-Bombays is (2)

Answer 16

a mutated FUT1 (H gene) with or without an active FUT2 gene (Se gene) or a silenced FUT1 gene with an active FUT2 gene.

Question 17

• a rare group 1 discrepancy.

- presence of two cell populations in single individual like in cases of fraternal twins

Answer 17

CHIMERISM

Question 18

when bacterial enzymes (of Proteus vulgaris) modify N-acetylgalactosamine into D- galactose)

Answer 18

ACQUIRED B phenomenon

Question 19

ACQUIRED B phenomenon - when bacterial enzymes (of what bacteria?) modify N-acetylgalactosamine into D- galactose)

Answer 19

Proteus vulgaris)