SI LEC - Innate Immunity Part 3 Flashcards
Covered by long membranous extensions
Dendritic cells
dendritic cell in
skin/mucous membrane
Langerhans cells:
dendritic cell
organs like heart
Interstitial cell:
dendritic cell
T lympho areas in secondary lymphoid organs
Interdigitating cell:
cytokines are critical for host defense.
inflammatory cytokines
ex of inflammatory cytokines
activates macrophage and PMN phagocytosis and killing
TNFa
ex of inflammatory cytokines
activates anti-viral mechanisms
IFNab
ex of inflammatory cytokines
stimulates inflammation and fever
IL-1
Cytokines
- can function in __ or __ manner
autocrine or paracrine
bind specific and sometimes shared receptors to recruit various types of immune cells to the site of infection
chemokines
-diverse family of chemotactic cytokines, induce directed chemotaxis of cells
all related in amino acid structure
- promiscuous in receptor usage, each can bind more than one receptor
- likewise, receptors are promiscuous
Chemokines
certain chemokines induce cell ____ in addition to cell recruitment
activation
smallest granulocyte
basophilia
protein discovered in drosophilia (fruit fly) (antifungal)
Toll
Toll: protein discovered in
drosophilia (fruit fly) (antifungal)
TLR for bacterial parasites
TLR 1 and TLR 2
TLR for gram negative bacteria and fungi
TLR 2 and TLR 6
TLR for gram +
TLR 4
TLR for flagellated
TLR 5&7
TLR for viral dsRNA
TLR 3
TLR for viral ssRNA
TLR 3& 7
Bacterial DNA elements
TLR9
what TLRs: Lysosomal localization / what TLRs are subcellular
TLR-3 and TLR7-9
TLR-??
recognize viral/bacterial nucleic acids
TLR-3 and 7-9
