HEMA LEC 2 - MDs/MPNs Classification

Question 1

-persistent monocytosis of > 1.0 monocyte x 10^9/L

Answer 1

Chronic Myelomonocytic Leukemia

Question 2

-increased WBC count with absolute monocytosis

Answer 2

Chronic Myelomonocytic Leukemia

Question 3

-characterized by leukocytosis with dysplastic neut and their precursors

Answer 3

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

Question 4

multilineage dysplasia → common

Answer 4

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

Question 5

dyspoiesis may be seen in all cell lines, but most remarkable in neut, which may exbit Pelger-Huet-like cells, hypogranularity and bizarre segmentation

Answer 5

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

Question 6

-with strong association with neurofibromatosis type 1

Answer 6

Juvenile Myelomonocytic Leukemia

Question 7

-clonal disorder characterized by proliferation of the granulocytic and monocytic cell lines

Answer 7

Juvenile Myelomonocytic Leukemia

Question 8

-affects children from 1month to 4 y/o

Answer 8

Juvenile Myelomonocytic Leukemia

Question 9

-allogeneic stem cell transplantation effective in about half of patients

Answer 9

Juvenile Myelomonocytic Leukemia

Question 10

-includes cases that meet the criteria for MDS/MPN but do not fit into one of the specified subcategories

Answer 10

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

Question 11

-features of RARS-T and also carries the JAK2 V617F mutation

Answer 11

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable